Plasma vacular endothelial growth factor, soluble VEGF receptor flt-1 and von Willebrand factor in glaucoma

Research output: Contribution to journalArticle

Authors

  • Peck-Lin Lip
  • Dirk Felmeden
  • Andrew Blann
  • N Matheou
  • S Thakur
  • Ian Cunliffe

Abstract

Aim: To investigate plasma indices of vascular permeability (vascular endothelial growth factor, VEGF-also an index of angiogenesis, as well as the soluble receptor for VEGF, sFlt-1) and endothelial damage/dysfunction (von Willebrand factor, vWf) in glaucoma. Methods: Citrated plasma was assayed for VEGF, sFlt-1, and vWf (all ELISA) in a cross sectional study of 50 patients (20 male; mean age 63.9 years, SD 10.5) with glaucoma: 26 had normal tension glaucoma (NTG) and 24 had primary open angle glaucoma (POAG), who were compared with 26 healthy controls (mean age 73.4 years, SD 9.2). Results: Median (interquartile range, IQR) levels of VEGF were significantly elevated in patients with NTG and POAG compared to healthy controls (Kruskal-Wallis test, p

Details

Original languageEnglish
Pages (from-to)1299-1302
Number of pages4
JournalBritish Journal of Ophthalmology
Volume86
Issue number11
Publication statusPublished - 1 Nov 2002