Plasma markers of angiogenesis in pregnancy induced hypertension

Research output: Contribution to journalArticle

Standard

Plasma markers of angiogenesis in pregnancy induced hypertension. / Nadar, SK; Karalis, I; Al Yemeni, E; Blann, Andrew; Lip, Gregory.

In: Thrombosis and Haemostasis, Vol. 94, No. 5, 01.11.2005, p. 1071-6.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Nadar, SK ; Karalis, I ; Al Yemeni, E ; Blann, Andrew ; Lip, Gregory. / Plasma markers of angiogenesis in pregnancy induced hypertension. In: Thrombosis and Haemostasis. 2005 ; Vol. 94, No. 5. pp. 1071-6.

Bibtex

@article{d2647b2fb06c47858a7b5990e69a522d,
title = "Plasma markers of angiogenesis in pregnancy induced hypertension",
abstract = "This study tests the hypothesis that abnormalities in plasma indices of angiogenesis, such as Vascular Endothelial Growth Factor (VEGF) and angiopoietins (Ang-1, Ang-2), as well as their soluble receptors Flt-1 (sFlt-1) and Tie 2 (sTie-2) respectively, are present in women with in pregnancy-induced hypertension (PIH). We also measured platelet levels of VEGF and Ang-1 (pVEGF and pAng-1 respectively). We studied 69 consecutive women with PIH (34 without proteinuria, and 35 with proteinuria, i.e. preeclampsia) who were compared to 64 consecutive women with normotensive pregnancies and 30 normotensive non-pregnant women, in a cross-sectional study. Using ELISA, we measured levels of plasma VEGF, Ang-1 & 2, Tie-2 and sFlt-1, and also the levels of angiogenic markers within the platelet [platelet VEGF (pVEGF) and platelet Ang-1 (pAng1)] by lysing a fixed number of platelets with 0.5% tween. Results show that levels of plasma VEGF, Ang-1, Ang2, sFlt-1 and Tie-2 were significantly different between the study groups. Post hoc analyses revealed plasma Ang-1 was highest in the preeclampsia group (p",
author = "SK Nadar and I Karalis and {Al Yemeni}, E and Andrew Blann and Gregory Lip",
year = "2005",
month = nov,
day = "1",
doi = "10.1160/TH05-05-1071",
language = "English",
volume = "94",
pages = "1071--6",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer",
number = "5",

}

RIS

TY - JOUR

T1 - Plasma markers of angiogenesis in pregnancy induced hypertension

AU - Nadar, SK

AU - Karalis, I

AU - Al Yemeni, E

AU - Blann, Andrew

AU - Lip, Gregory

PY - 2005/11/1

Y1 - 2005/11/1

N2 - This study tests the hypothesis that abnormalities in plasma indices of angiogenesis, such as Vascular Endothelial Growth Factor (VEGF) and angiopoietins (Ang-1, Ang-2), as well as their soluble receptors Flt-1 (sFlt-1) and Tie 2 (sTie-2) respectively, are present in women with in pregnancy-induced hypertension (PIH). We also measured platelet levels of VEGF and Ang-1 (pVEGF and pAng-1 respectively). We studied 69 consecutive women with PIH (34 without proteinuria, and 35 with proteinuria, i.e. preeclampsia) who were compared to 64 consecutive women with normotensive pregnancies and 30 normotensive non-pregnant women, in a cross-sectional study. Using ELISA, we measured levels of plasma VEGF, Ang-1 & 2, Tie-2 and sFlt-1, and also the levels of angiogenic markers within the platelet [platelet VEGF (pVEGF) and platelet Ang-1 (pAng1)] by lysing a fixed number of platelets with 0.5% tween. Results show that levels of plasma VEGF, Ang-1, Ang2, sFlt-1 and Tie-2 were significantly different between the study groups. Post hoc analyses revealed plasma Ang-1 was highest in the preeclampsia group (p

AB - This study tests the hypothesis that abnormalities in plasma indices of angiogenesis, such as Vascular Endothelial Growth Factor (VEGF) and angiopoietins (Ang-1, Ang-2), as well as their soluble receptors Flt-1 (sFlt-1) and Tie 2 (sTie-2) respectively, are present in women with in pregnancy-induced hypertension (PIH). We also measured platelet levels of VEGF and Ang-1 (pVEGF and pAng-1 respectively). We studied 69 consecutive women with PIH (34 without proteinuria, and 35 with proteinuria, i.e. preeclampsia) who were compared to 64 consecutive women with normotensive pregnancies and 30 normotensive non-pregnant women, in a cross-sectional study. Using ELISA, we measured levels of plasma VEGF, Ang-1 & 2, Tie-2 and sFlt-1, and also the levels of angiogenic markers within the platelet [platelet VEGF (pVEGF) and platelet Ang-1 (pAng1)] by lysing a fixed number of platelets with 0.5% tween. Results show that levels of plasma VEGF, Ang-1, Ang2, sFlt-1 and Tie-2 were significantly different between the study groups. Post hoc analyses revealed plasma Ang-1 was highest in the preeclampsia group (p

U2 - 10.1160/TH05-05-1071

DO - 10.1160/TH05-05-1071

M3 - Article

C2 - 16363251

VL - 94

SP - 1071

EP - 1076

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 5

ER -