Plasma haemoxygenase-1 in coronary artery disease A comparison with angiogenin, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and vascular endothelial growth factor

Research output: Contribution to journalArticle

Authors

  • NK Idriss
  • B Balakrishnan
  • Rumi Jaumdally
  • Christopher Boos
  • Andrew Blann

Abstract

It was the aim of this study to determine plasma haemoxygenase 1 (HO 1) across the spectrum of health, angina but normal coronary arteries (NCA) stable coronary artery disease (CAD) and acute coronary syndromes (ACS) and relationships with angiogenin matrix metallo proteinase 9 (MMP 9), tissue inhibitor of metalloproteinase 1, and vascular endothelial growth factor Plasma markers were measured (ELISA) in peripheral venous citrated plasma from 50 healthy subjects 30 with NCA, 70 with stable CAD and 24 with an ACS and from patient s aortic root coronary ostium coronary sinus and femoral artery Human umbilical vein endothelial cells (HUVECs) were cultured with or without tumour necrosis factor (TNF) and platelets were probed HO 1 was raised in stable CAD (p

Details

Original languageEnglish
Pages (from-to)1029-1037
Number of pages9
JournalThrombosis and Haemostasis
Volume104
Issue number5
Publication statusPublished - 1 Nov 2010

Keywords

  • coronary artery disease, vascular endothelial growth factor, tissue inhibitor of metalloproteinase, Haemoxygenase 1 angiogenin matrix metalloproteinase 9