Plasma amino acid levels in children with autism and their families

Research output: Contribution to journalArticle

Authors

Abstract

Plasma amino acid levels were measured in autistic and Asperger syndrome patients, their siblings, and parents. The results were compared with values from age-matched controls. Patients with autism or Asperger syndrome and their siblings and parents all had raised glutamic acid, phenylalanine, asparagine, tyrosine, alanine, and lysine (p <.05) than controls, with reduced plasma glutamine. Other amino acids were at normal levels. These results show that children with autistic spectrum disorders come from a family background of dysregulated amino acid metabolism and provide further evidence for an underlying biochemical basis for the condition.

Details

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalJournal of Autism and Developmental Disorders
Volume33
Publication statusPublished - 1 Jan 2003

Keywords

  • plasma, autism, amino acids, glutamate/glutamine ratio, Asperger syndrome