Placental iodothyronine deiodinase expression in normal and growth restricted human pregnancies

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We have described the expression of specific iodothyronine deiodinase mRNAs (using quantitative RT-PCR) and activities in normal human placentas throughout gestation and compared our findings to those in placentas from pregnancies affected by intrauterine growth restriction (IUGR). The predominant deiodinase expressed in placenta was type III (D3); type II (D2) was also present. In general terms, the activities of the enzymes D2 and D3 (and mRNAs encoding these enzymes) were higher earlier in gestation (


Original languageEnglish
Pages (from-to)4488-4495
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Issue number9
Publication statusPublished - 1 Sep 2003