Physiological and proteomic approaches to understanding human sperm function: Prefertilization events
Research output: Chapter in Book/Report/Conference proceeding › Chapter
- Reproductive Biology and Genetics Group
- Assisted Conception Unit
- Birmingham Women'es Hospital
Sperm dysfunction is the single most common defined cause of infertility. Approximately 1 in 15 men are subfertile and the condition is increasing in frequency. However, the diagnosis is poor and, excluding assisted conception, there is no treatment because of our limited understanding of the cellular, biochemical, and molecular functioning of the spermatozoon. The underlying premise of our research program is to establish a rudimentary understanding of the processes necessary for successful fertilization. We detail advances in our understanding of calcium signaling in the cell and outline genetic and proteomic technologies that are being used to improve the diagnosis of the condition.
|Title of host publication||The Genetics of Male Infertility|
|Publication status||Published - 1 Jan 2007|