Physical activity for cancer survivors: meta-analysis of randomised controlled trials

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Physical activity for cancer survivors: meta-analysis of randomised controlled trials. / Fong, DYT; Ho, JWC; Hui, BPH; Lee, AM; Macfarlane, DJ; Leung, SSK; Cerin, E; Chan, WYY; Leung, IPF; Lam, SHS; Taylor, Aliki; Cheng, Kar.

In: British Medical Journal (International edition), Vol. 344, No. 7844, e70, 01.01.2012, p. 17.

Research output: Contribution to journalArticle

Harvard

Fong, DYT, Ho, JWC, Hui, BPH, Lee, AM, Macfarlane, DJ, Leung, SSK, Cerin, E, Chan, WYY, Leung, IPF, Lam, SHS, Taylor, A & Cheng, K 2012, 'Physical activity for cancer survivors: meta-analysis of randomised controlled trials', British Medical Journal (International edition), vol. 344, no. 7844, e70, pp. 17. https://doi.org/10.1136/bmj.e70

APA

Fong, DYT., Ho, JWC., Hui, BPH., Lee, AM., Macfarlane, DJ., Leung, SSK., Cerin, E., Chan, WYY., Leung, IPF., Lam, SHS., Taylor, A., & Cheng, K. (2012). Physical activity for cancer survivors: meta-analysis of randomised controlled trials. British Medical Journal (International edition), 344(7844), 17. [e70]. https://doi.org/10.1136/bmj.e70

Vancouver

Author

Fong, DYT ; Ho, JWC ; Hui, BPH ; Lee, AM ; Macfarlane, DJ ; Leung, SSK ; Cerin, E ; Chan, WYY ; Leung, IPF ; Lam, SHS ; Taylor, Aliki ; Cheng, Kar. / Physical activity for cancer survivors: meta-analysis of randomised controlled trials. In: British Medical Journal (International edition). 2012 ; Vol. 344, No. 7844. pp. 17.

Bibtex

@article{38d18a7d22194882970bab5b72e115b2,
title = "Physical activity for cancer survivors: meta-analysis of randomised controlled trials",
abstract = "OBJECTIVE To systematically evaluate the effects of physical activity in adult patients after completion of main treatment related to cancer. DESIGN Meta-analysis of randomised controlled trials with data extraction and quality assessment performed independently by two researchers. DATA SOURCES PUBMED, CINAHL, and Google Scholar from the earliest possible year to September 2011. References from meta-analyses and reviews. STUDY selection Randomised controlled trials that assessed the effects of physical activity in adults who had completed their main cancer treatment, except hormonal treatment. RESULTS There were 34 randomised controlled trials, of which 22 (65%) focused on patients with breast cancer, and 48 outcomes in our meta-analysis. Twenty two studies assessed aerobic exercise, and four also included resistance or strength training. The median duration of physical activity was 13 weeks (range 3-60 weeks). Most control groups were considered sedentary or were assigned no exercise. Based on studies on patients with breast cancer, physical activity was associated with improvements in insulin-like growth factor-I, bench press, leg press, fatigue, depression, and quality of life. When we combined studies on different types of cancer, we found significant improvements in body mass index (BMI), body weight, peak oxygen consumption, peak power output, distance walked in six minutes, right handgrip strength, and quality of life. Sources of study heterogeneity included age, study quality, study size, and type and duration of physical activity. Publication bias did not alter our conclusions. CONCLUSIONS Physical activity has positive effects on physiology, body composition, physical functions, psychological outcomes, and quality of life in patients after treatment for breast cancer. When patients with cancer other than breast cancer were also included, physical activity was associated with reduced BMI and body weight, increased peak oxygen consumption and peak power output, and improved quality of life.",
author = "DYT Fong and JWC Ho and BPH Hui and AM Lee and DJ Macfarlane and SSK Leung and E Cerin and WYY Chan and IPF Leung and SHS Lam and Aliki Taylor and Kar Cheng",
year = "2012",
month = jan,
day = "1",
doi = "10.1136/bmj.e70",
language = "English",
volume = "344",
pages = "17",
journal = "British Medical Journal (International edition)",
issn = "0959-8146",
publisher = "BMJ Publishing Group",
number = "7844",

}

RIS

TY - JOUR

T1 - Physical activity for cancer survivors: meta-analysis of randomised controlled trials

AU - Fong, DYT

AU - Ho, JWC

AU - Hui, BPH

AU - Lee, AM

AU - Macfarlane, DJ

AU - Leung, SSK

AU - Cerin, E

AU - Chan, WYY

AU - Leung, IPF

AU - Lam, SHS

AU - Taylor, Aliki

AU - Cheng, Kar

PY - 2012/1/1

Y1 - 2012/1/1

N2 - OBJECTIVE To systematically evaluate the effects of physical activity in adult patients after completion of main treatment related to cancer. DESIGN Meta-analysis of randomised controlled trials with data extraction and quality assessment performed independently by two researchers. DATA SOURCES PUBMED, CINAHL, and Google Scholar from the earliest possible year to September 2011. References from meta-analyses and reviews. STUDY selection Randomised controlled trials that assessed the effects of physical activity in adults who had completed their main cancer treatment, except hormonal treatment. RESULTS There were 34 randomised controlled trials, of which 22 (65%) focused on patients with breast cancer, and 48 outcomes in our meta-analysis. Twenty two studies assessed aerobic exercise, and four also included resistance or strength training. The median duration of physical activity was 13 weeks (range 3-60 weeks). Most control groups were considered sedentary or were assigned no exercise. Based on studies on patients with breast cancer, physical activity was associated with improvements in insulin-like growth factor-I, bench press, leg press, fatigue, depression, and quality of life. When we combined studies on different types of cancer, we found significant improvements in body mass index (BMI), body weight, peak oxygen consumption, peak power output, distance walked in six minutes, right handgrip strength, and quality of life. Sources of study heterogeneity included age, study quality, study size, and type and duration of physical activity. Publication bias did not alter our conclusions. CONCLUSIONS Physical activity has positive effects on physiology, body composition, physical functions, psychological outcomes, and quality of life in patients after treatment for breast cancer. When patients with cancer other than breast cancer were also included, physical activity was associated with reduced BMI and body weight, increased peak oxygen consumption and peak power output, and improved quality of life.

AB - OBJECTIVE To systematically evaluate the effects of physical activity in adult patients after completion of main treatment related to cancer. DESIGN Meta-analysis of randomised controlled trials with data extraction and quality assessment performed independently by two researchers. DATA SOURCES PUBMED, CINAHL, and Google Scholar from the earliest possible year to September 2011. References from meta-analyses and reviews. STUDY selection Randomised controlled trials that assessed the effects of physical activity in adults who had completed their main cancer treatment, except hormonal treatment. RESULTS There were 34 randomised controlled trials, of which 22 (65%) focused on patients with breast cancer, and 48 outcomes in our meta-analysis. Twenty two studies assessed aerobic exercise, and four also included resistance or strength training. The median duration of physical activity was 13 weeks (range 3-60 weeks). Most control groups were considered sedentary or were assigned no exercise. Based on studies on patients with breast cancer, physical activity was associated with improvements in insulin-like growth factor-I, bench press, leg press, fatigue, depression, and quality of life. When we combined studies on different types of cancer, we found significant improvements in body mass index (BMI), body weight, peak oxygen consumption, peak power output, distance walked in six minutes, right handgrip strength, and quality of life. Sources of study heterogeneity included age, study quality, study size, and type and duration of physical activity. Publication bias did not alter our conclusions. CONCLUSIONS Physical activity has positive effects on physiology, body composition, physical functions, psychological outcomes, and quality of life in patients after treatment for breast cancer. When patients with cancer other than breast cancer were also included, physical activity was associated with reduced BMI and body weight, increased peak oxygen consumption and peak power output, and improved quality of life.

U2 - 10.1136/bmj.e70

DO - 10.1136/bmj.e70

M3 - Article

C2 - 22294757

VL - 344

SP - 17

JO - British Medical Journal (International edition)

JF - British Medical Journal (International edition)

SN - 0959-8146

IS - 7844

M1 - e70

ER -