Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome

Research output: Contribution to journalArticle

Authors

  • Wan Fai Ng
  • Ariana Miller
  • Simon J. Bowman
  • Elizabeth J. Price
  • George D. Kitas
  • Colin Pease
  • Paul Emery
  • Peter Lanyon
  • John Hunter
  • Monica Gupta
  • Ian Giles
  • David Isenberg
  • John McLaren
  • Marian Regan
  • Annie Cooper
  • Steven A. Young-Min
  • Neil McHugh
  • Saravanan Vadivelu
  • Robert J. Moots
  • David Coady
  • Kirsten MacKay
  • Bhaskar Dasgupta
  • Nurhan Sutcliffe
  • Michele Bombardieri
  • Costantino Pitzalis
  • Bridget Griffiths
  • Sheryl Mitchell
  • Samira Tatiyama Miyamoto
  • Michael Trenell
  • Frances Hall
  • Elalaine C. Bacabac
  • Kuntal Chakravarty
  • Shamin Lamabadusuriya
  • Nagui Gendi
  • Rashidat Adeniba
  • John Hamburger
  • Andrea Richards
  • Saaeha Rauz
  • Sue Brailsford
  • Joanne Logan
  • Diarmuid Mulherin
  • Jacqueline Andrews
  • Alison McManus
  • Alison Booth
  • Theodoros Dimitroulas
  • Lucy Kadiki
  • Daljit Kaur
  • Mark Lloyd
  • Susan Knight
  • Adrian Jones
  • UK Primary Sjögren’s Syndrome Registry

Colleges, School and Institutes

External organisations

  • Newcastle University
  • University Hospitals Birmingham NHS Trust
  • NHS Foundation Trust
  • Dudley Group of Hospitals NHS Trust
  • University of Leeds
  • Nottingham University Hospitals NHS Trust
  • Gartnavel General Hospital
  • UCL
  • NHS Fife
  • Royal Derby Hospital
  • Royal Hampshire County Hospital
  • Portsmouth Hospitals NHS Trust
  • Royal National Hospital for Rheumatic Diseases
  • Queen Elizabeth Hospital, Gateshead
  • Aintree University Hospitals NHS Foundation Trust
  • Royal Sunderland Hospital
  • Torbay Hospital
  • Southend Hospital
  • Barts and The London Queen Mary's School of Medicine and Dentistry
  • Universidade Federal do Espirito Santo

Abstract

The aim of the study was to evaluate the levels of physical activity in individuals with primary Sjögren’s syndrome (PSS) and its relationship to the clinical features of PSS. To this cross-sectional study, self-reported levels of physical activity from 273 PSS patients were measured using the International Physical Activity Questionnaire-short form (IPAQ-SF) and were compared with healthy controls matched for age, sex and body mass index. Fatigue and other clinical aspects of PSS including disease status, dryness, daytime sleepiness, dysautonomia, anxiety and depression were assessed using validated tools. Individuals with PSS had significantly reduced levels of physical activity [median (interquartile range, IQR) 1572 (594–3158) versus 3708 (1732–8255) metabolic equivalent of task (MET) × min/week, p < 0.001], but similar levels of sedentary activity [median (IQR) min 300 (135–375) versus 343 (223–433) (MET) × min/week, p = 0.532] compared to healthy individuals. Differences in physical activity between PSS and controls increased at moderate [median (IQR) 0 (0–480) versus 1560 (570–3900) MET × min/week, p < 0.001] and vigorous intensities [median (IQR) 0 (0–480) versus 480 (0–1920) MET × min/week, p < 0.001]. Correlation analysis revealed a significant association between physical activity and fatigue, orthostatic intolerance, depressive symptoms and quality of life. Sedentary activity did not correlate with fatigue. Stepwise linear regression analysis identified symptoms of depression and daytime sleepiness as independent predictors of levels of physical activity. Physical activity is reduced in people with PSS and is associated with symptoms of depression and daytime sleepiness. Sedentary activity is not increased in PSS. Clinical care teams should explore the clinical utility of targeting low levels of physical activity in PSS.

Details

Original languageEnglish
Pages (from-to)623-631
Number of pages9
JournalRheumatology International
Volume37
Issue number4
Early online date24 Dec 2016
Publication statusPublished - Apr 2017

Keywords

  • Fatigue, Patient registry, Patient-reported outcomes, Physical activity, Primary Sjögren’s syndrome