Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome

Wan Fai Ng; Ariana Miller; Simon J. Bowman; Elizabeth J. Price; George D. Kitas; Colin Pease; Paul Emery; Peter Lanyon; John Hunter; Monica Gupta; Ian Giles; David Isenberg; John McLaren; Marian Regan; Annie Cooper; Steven A. Young-Min; Neil McHugh; Saravanan Vadivelu; Robert J. Moots; David Coady; Kirsten MacKay; Bhaskar Dasgupta; Nurhan Sutcliffe; Michele Bombardieri; Costantino Pitzalis; Bridget Griffiths; Sheryl Mitchell; Samira Tatiyama Miyamoto; Michael Trenell; Frances Hall; Elalaine C. Bacabac; Kuntal Chakravarty; Shamin Lamabadusuriya; Nagui Gendi; Rashidat Adeniba; John Hamburger; Andrea Richards; Saaeha Rauz; Sue Brailsford; Joanne Logan; Diarmuid Mulherin; Jacqueline Andrews; Alison McManus; Alison Booth; Theodoros Dimitroulas; Lucy Kadiki; Daljit Kaur; Mark Lloyd; Susan Knight; Adrian Jones; UK Primary Sjögren’s Syndrome Registry

doi:10.1007/s00296-016-3637-6

Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome

Wan Fai Ng^*, Ariana Miller, Simon J. Bowman, Elizabeth J. Price, George D. Kitas, Colin Pease, Paul Emery, Peter Lanyon, John Hunter, Monica Gupta, Ian Giles, David Isenberg, John McLaren, Marian Regan, Annie Cooper, Steven A. Young-Min, Neil McHugh, Saravanan Vadivelu, Robert J. Moots, David CoadyKirsten MacKay, Bhaskar Dasgupta, Nurhan Sutcliffe, Michele Bombardieri, Costantino Pitzalis, Bridget Griffiths, Sheryl Mitchell, Samira Tatiyama Miyamoto, Michael Trenell, Frances Hall, Elalaine C. Bacabac, Kuntal Chakravarty, Shamin Lamabadusuriya, Nagui Gendi, Rashidat Adeniba, John Hamburger, Andrea Richards, Saaeha Rauz, Sue Brailsford, Joanne Logan, Diarmuid Mulherin, Jacqueline Andrews, Alison McManus, Alison Booth, Theodoros Dimitroulas, Lucy Kadiki, Daljit Kaur, Mark Lloyd, Susan Knight, Adrian Jones, UK Primary Sjögren’s Syndrome Registry

^*Corresponding author for this work

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Abstract

The aim of the study was to evaluate the levels of physical activity in individuals with primary Sjögren’s syndrome (PSS) and its relationship to the clinical features of PSS. To this cross-sectional study, self-reported levels of physical activity from 273 PSS patients were measured using the International Physical Activity Questionnaire-short form (IPAQ-SF) and were compared with healthy controls matched for age, sex and body mass index. Fatigue and other clinical aspects of PSS including disease status, dryness, daytime sleepiness, dysautonomia, anxiety and depression were assessed using validated tools. Individuals with PSS had significantly reduced levels of physical activity [median (interquartile range, IQR) 1572 (594–3158) versus 3708 (1732–8255) metabolic equivalent of task (MET) × min/week, p < 0.001], but similar levels of sedentary activity [median (IQR) min 300 (135–375) versus 343 (223–433) (MET) × min/week, p = 0.532] compared to healthy individuals. Differences in physical activity between PSS and controls increased at moderate [median (IQR) 0 (0–480) versus 1560 (570–3900) MET × min/week, p < 0.001] and vigorous intensities [median (IQR) 0 (0–480) versus 480 (0–1920) MET × min/week, p < 0.001]. Correlation analysis revealed a significant association between physical activity and fatigue, orthostatic intolerance, depressive symptoms and quality of life. Sedentary activity did not correlate with fatigue. Stepwise linear regression analysis identified symptoms of depression and daytime sleepiness as independent predictors of levels of physical activity. Physical activity is reduced in people with PSS and is associated with symptoms of depression and daytime sleepiness. Sedentary activity is not increased in PSS. Clinical care teams should explore the clinical utility of targeting low levels of physical activity in PSS.

Original language	English
Pages (from-to)	623-631
Number of pages	9
Journal	Rheumatology International
Volume	37
Issue number	4
Early online date	24 Dec 2016
DOIs	https://doi.org/10.1007/s00296-016-3637-6
Publication status	Published - Apr 2017

Keywords

Fatigue
Patient registry
Patient-reported outcomes
Physical activity
Primary Sjögren’s syndrome

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

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Wan_Fai_Ng_et_al_Physical_activity_but_not_sedentary_Rheumatology_International_2017
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Ng, W. F., Miller, A., Bowman, S. J., Price, E. J., Kitas, G. D., Pease, C., Emery, P., Lanyon, P., Hunter, J., Gupta, M., Giles, I., Isenberg, D., McLaren, J., Regan, M., Cooper, A., Young-Min, S. A., McHugh, N., Vadivelu, S., Moots, R. J., ... UK Primary Sjögren’s Syndrome Registry (2017). Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome. Rheumatology International, 37(4), 623-631. Advance online publication. https://doi.org/10.1007/s00296-016-3637-6

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title = "Physical activity but not sedentary activity is reduced in primary Sj{\"o}gren{\textquoteright}s syndrome",

abstract = "The aim of the study was to evaluate the levels of physical activity in individuals with primary Sj{\"o}gren{\textquoteright}s syndrome (PSS) and its relationship to the clinical features of PSS. To this cross-sectional study, self-reported levels of physical activity from 273 PSS patients were measured using the International Physical Activity Questionnaire-short form (IPAQ-SF) and were compared with healthy controls matched for age, sex and body mass index. Fatigue and other clinical aspects of PSS including disease status, dryness, daytime sleepiness, dysautonomia, anxiety and depression were assessed using validated tools. Individuals with PSS had significantly reduced levels of physical activity [median (interquartile range, IQR) 1572 (594–3158) versus 3708 (1732–8255) metabolic equivalent of task (MET) × min/week, p < 0.001], but similar levels of sedentary activity [median (IQR) min 300 (135–375) versus 343 (223–433) (MET) × min/week, p = 0.532] compared to healthy individuals. Differences in physical activity between PSS and controls increased at moderate [median (IQR) 0 (0–480) versus 1560 (570–3900) MET × min/week, p < 0.001] and vigorous intensities [median (IQR) 0 (0–480) versus 480 (0–1920) MET × min/week, p < 0.001]. Correlation analysis revealed a significant association between physical activity and fatigue, orthostatic intolerance, depressive symptoms and quality of life. Sedentary activity did not correlate with fatigue. Stepwise linear regression analysis identified symptoms of depression and daytime sleepiness as independent predictors of levels of physical activity. Physical activity is reduced in people with PSS and is associated with symptoms of depression and daytime sleepiness. Sedentary activity is not increased in PSS. Clinical care teams should explore the clinical utility of targeting low levels of physical activity in PSS.",

keywords = "Fatigue, Patient registry, Patient-reported outcomes, Physical activity, Primary Sj{\"o}gren{\textquoteright}s syndrome",

author = "Ng, {Wan Fai} and Ariana Miller and Bowman, {Simon J.} and Price, {Elizabeth J.} and Kitas, {George D.} and Colin Pease and Paul Emery and Peter Lanyon and John Hunter and Monica Gupta and Ian Giles and David Isenberg and John McLaren and Marian Regan and Annie Cooper and Young-Min, {Steven A.} and Neil McHugh and Saravanan Vadivelu and Moots, {Robert J.} and David Coady and Kirsten MacKay and Bhaskar Dasgupta and Nurhan Sutcliffe and Michele Bombardieri and Costantino Pitzalis and Bridget Griffiths and Sheryl Mitchell and Miyamoto, {Samira Tatiyama} and Michael Trenell and Frances Hall and Bacabac, {Elalaine C.} and Kuntal Chakravarty and Shamin Lamabadusuriya and Nagui Gendi and Rashidat Adeniba and John Hamburger and Andrea Richards and Saaeha Rauz and Sue Brailsford and Joanne Logan and Diarmuid Mulherin and Jacqueline Andrews and Alison McManus and Alison Booth and Theodoros Dimitroulas and Lucy Kadiki and Daljit Kaur and Mark Lloyd and Susan Knight and Adrian Jones and {UK Primary Sj{\"o}gren{\textquoteright}s Syndrome Registry}",

year = "2017",

month = apr,

doi = "10.1007/s00296-016-3637-6",

language = "English",

volume = "37",

pages = "623--631",

journal = "Rheumatology International",

issn = "0172-8172",

publisher = "Springer",

number = "4",

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Ng, WF, Miller, A, Bowman, SJ, Price, EJ, Kitas, GD, Pease, C, Emery, P, Lanyon, P, Hunter, J, Gupta, M, Giles, I, Isenberg, D, McLaren, J, Regan, M, Cooper, A, Young-Min, SA, McHugh, N, Vadivelu, S, Moots, RJ, Coady, D, MacKay, K, Dasgupta, B, Sutcliffe, N, Bombardieri, M, Pitzalis, C, Griffiths, B, Mitchell, S, Miyamoto, ST, Trenell, M, Hall, F, Bacabac, EC, Chakravarty, K, Lamabadusuriya, S, Gendi, N, Adeniba, R, Hamburger, J, Richards, A, Rauz, S, Brailsford, S, Logan, J, Mulherin, D, Andrews, J, McManus, A, Booth, A, Dimitroulas, T, Kadiki, L, Kaur, D, Lloyd, M, Knight, S, Jones, A & UK Primary Sjögren’s Syndrome Registry 2017, 'Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome', Rheumatology International, vol. 37, no. 4, pp. 623-631. https://doi.org/10.1007/s00296-016-3637-6

TY - JOUR

T1 - Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome

AU - Ng, Wan Fai

AU - Miller, Ariana

AU - Bowman, Simon J.

AU - Price, Elizabeth J.

AU - Kitas, George D.

AU - Pease, Colin

AU - Emery, Paul

AU - Lanyon, Peter

AU - Hunter, John

AU - Gupta, Monica

AU - Giles, Ian

AU - Isenberg, David

AU - McLaren, John

AU - Regan, Marian

AU - Cooper, Annie

AU - Young-Min, Steven A.

AU - McHugh, Neil

AU - Vadivelu, Saravanan

AU - Moots, Robert J.

AU - Coady, David

AU - MacKay, Kirsten

AU - Dasgupta, Bhaskar

AU - Sutcliffe, Nurhan

AU - Bombardieri, Michele

AU - Pitzalis, Costantino

AU - Griffiths, Bridget

AU - Mitchell, Sheryl

AU - Miyamoto, Samira Tatiyama

AU - Trenell, Michael

AU - Hall, Frances

AU - Bacabac, Elalaine C.

AU - Chakravarty, Kuntal

AU - Lamabadusuriya, Shamin

AU - Gendi, Nagui

AU - Adeniba, Rashidat

AU - Hamburger, John

AU - Richards, Andrea

AU - Rauz, Saaeha

AU - Brailsford, Sue

AU - Logan, Joanne

AU - Mulherin, Diarmuid

AU - Andrews, Jacqueline

AU - McManus, Alison

AU - Booth, Alison

AU - Dimitroulas, Theodoros

AU - Kadiki, Lucy

AU - Kaur, Daljit

AU - Lloyd, Mark

AU - Knight, Susan

AU - Jones, Adrian

AU - UK Primary Sjögren’s Syndrome Registry

PY - 2017/4

Y1 - 2017/4

N2 - The aim of the study was to evaluate the levels of physical activity in individuals with primary Sjögren’s syndrome (PSS) and its relationship to the clinical features of PSS. To this cross-sectional study, self-reported levels of physical activity from 273 PSS patients were measured using the International Physical Activity Questionnaire-short form (IPAQ-SF) and were compared with healthy controls matched for age, sex and body mass index. Fatigue and other clinical aspects of PSS including disease status, dryness, daytime sleepiness, dysautonomia, anxiety and depression were assessed using validated tools. Individuals with PSS had significantly reduced levels of physical activity [median (interquartile range, IQR) 1572 (594–3158) versus 3708 (1732–8255) metabolic equivalent of task (MET) × min/week, p < 0.001], but similar levels of sedentary activity [median (IQR) min 300 (135–375) versus 343 (223–433) (MET) × min/week, p = 0.532] compared to healthy individuals. Differences in physical activity between PSS and controls increased at moderate [median (IQR) 0 (0–480) versus 1560 (570–3900) MET × min/week, p < 0.001] and vigorous intensities [median (IQR) 0 (0–480) versus 480 (0–1920) MET × min/week, p < 0.001]. Correlation analysis revealed a significant association between physical activity and fatigue, orthostatic intolerance, depressive symptoms and quality of life. Sedentary activity did not correlate with fatigue. Stepwise linear regression analysis identified symptoms of depression and daytime sleepiness as independent predictors of levels of physical activity. Physical activity is reduced in people with PSS and is associated with symptoms of depression and daytime sleepiness. Sedentary activity is not increased in PSS. Clinical care teams should explore the clinical utility of targeting low levels of physical activity in PSS.

AB - The aim of the study was to evaluate the levels of physical activity in individuals with primary Sjögren’s syndrome (PSS) and its relationship to the clinical features of PSS. To this cross-sectional study, self-reported levels of physical activity from 273 PSS patients were measured using the International Physical Activity Questionnaire-short form (IPAQ-SF) and were compared with healthy controls matched for age, sex and body mass index. Fatigue and other clinical aspects of PSS including disease status, dryness, daytime sleepiness, dysautonomia, anxiety and depression were assessed using validated tools. Individuals with PSS had significantly reduced levels of physical activity [median (interquartile range, IQR) 1572 (594–3158) versus 3708 (1732–8255) metabolic equivalent of task (MET) × min/week, p < 0.001], but similar levels of sedentary activity [median (IQR) min 300 (135–375) versus 343 (223–433) (MET) × min/week, p = 0.532] compared to healthy individuals. Differences in physical activity between PSS and controls increased at moderate [median (IQR) 0 (0–480) versus 1560 (570–3900) MET × min/week, p < 0.001] and vigorous intensities [median (IQR) 0 (0–480) versus 480 (0–1920) MET × min/week, p < 0.001]. Correlation analysis revealed a significant association between physical activity and fatigue, orthostatic intolerance, depressive symptoms and quality of life. Sedentary activity did not correlate with fatigue. Stepwise linear regression analysis identified symptoms of depression and daytime sleepiness as independent predictors of levels of physical activity. Physical activity is reduced in people with PSS and is associated with symptoms of depression and daytime sleepiness. Sedentary activity is not increased in PSS. Clinical care teams should explore the clinical utility of targeting low levels of physical activity in PSS.

KW - Fatigue

KW - Patient registry

KW - Patient-reported outcomes

KW - Physical activity

KW - Primary Sjögren’s syndrome

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U2 - 10.1007/s00296-016-3637-6

DO - 10.1007/s00296-016-3637-6

M3 - Article

C2 - 28013357

AN - SCOPUS:85007173745

SN - 0172-8172

VL - 37

SP - 623

EP - 631

JO - Rheumatology International

JF - Rheumatology International

IS - 4

ER -

Physical activity but not sedentary activity is reduced in primary Sjögren’s syndrome

Abstract

Keywords

ASJC Scopus subject areas

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