TY - JOUR
T1 - Photoperiod modulates melanoma growth in C57BL/6 Mice
AU - Lang, R
AU - Hintner, H
AU - Hermann, A
AU - Brandstaetter, Roland
PY - 2003/8/1
Y1 - 2003/8/1
N2 - Seasonal variations can be found in almost any parameter of an organism's biochemistry, physiology, endocrinology, and behaviour. This phenomenon, generally called photoperiodism, results from one of the major functions of the circadian system, i.e. the translation of environmental information into rhythmic intraorganismic signals, which then regulate or influence physiology and pathology. We induced melanoma in three groups of syngeneic C57BL/6 mice synchronised to different photoperiods (8, 12, or 18 h of light within 24-h days) by subcutaneous injections of HFH18 melanoma cell suspensions. All animals from all three photoperiodic groups developed exponentially growing tumors. The average tumor volume on day 31 post injection was significantly smaller in animals exposed to light/dark conditions (LD) 8 : 16 h as compared with animals held in LD 18 : 6 h and intermediate in animals from the equinox group. These results indicate that C57BL/6 mice react to photoperiod, which can exert a significant effect on tumor growth.
AB - Seasonal variations can be found in almost any parameter of an organism's biochemistry, physiology, endocrinology, and behaviour. This phenomenon, generally called photoperiodism, results from one of the major functions of the circadian system, i.e. the translation of environmental information into rhythmic intraorganismic signals, which then regulate or influence physiology and pathology. We induced melanoma in three groups of syngeneic C57BL/6 mice synchronised to different photoperiods (8, 12, or 18 h of light within 24-h days) by subcutaneous injections of HFH18 melanoma cell suspensions. All animals from all three photoperiodic groups developed exponentially growing tumors. The average tumor volume on day 31 post injection was significantly smaller in animals exposed to light/dark conditions (LD) 8 : 16 h as compared with animals held in LD 18 : 6 h and intermediate in animals from the equinox group. These results indicate that C57BL/6 mice react to photoperiod, which can exert a significant effect on tumor growth.
UR - http://www.scopus.com/inward/record.url?scp=0042063723&partnerID=8YFLogxK
U2 - 10.1034/j.1600-0625.2003.00004.x
DO - 10.1034/j.1600-0625.2003.00004.x
M3 - Article
C2 - 12930310
SN - 1600-0625
VL - 12
SP - 510
EP - 513
JO - Experimental Dermatology
JF - Experimental Dermatology
IS - 4
ER -