Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia: Testing the evidence for an endophenotypic marker

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Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia : Testing the evidence for an endophenotypic marker. / Brewer, Warrick J; Lin, Ashleigh; Moberg, Paul J; Smutzer, Gregory; Nelson, Barnaby; Yung, Alison R; Pantelis, Christos; McGorry, Patrick D; Turetsky, Bruce I; Wood, Stephen J.

In: Psychiatry Research, Vol. 199, No. 1, 2012, p. 8-11.

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Brewer, Warrick J ; Lin, Ashleigh ; Moberg, Paul J ; Smutzer, Gregory ; Nelson, Barnaby ; Yung, Alison R ; Pantelis, Christos ; McGorry, Patrick D ; Turetsky, Bruce I ; Wood, Stephen J. / Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia : Testing the evidence for an endophenotypic marker. In: Psychiatry Research. 2012 ; Vol. 199, No. 1. pp. 8-11.

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@article{6b734826ea1942798b921fde95db020e,
title = "Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia: Testing the evidence for an endophenotypic marker",
abstract = "Reports suggesting that schizophrenia participants are more likely to be phenylthiocarbamide (PTC) non-tasters when compared to controls have recently been controversial. If supported, a genetic-based phenotypic variation in PTC taster status is implicated, suggesting a greater illness risk for those participants with recessive alleles for the TAS2R38 receptor. Should PTC insensitivity be a schizophrenia endophenotype, then it would be expected in follow-up of ultra high-risk for psychosis participants who later develop schizophrenia (UHR-S). UHR-S was hypothesised to show reduced PTC sensitivity compared to those who were previously at risk, but did not transition (UHR-NP). PTC perception was assessed in 219 UHR participants at long-term follow-up, of whom 53 had transitioned to psychosis (UHR-P) during the follow-up period. Fifteen of the 219 participants were diagnosed with schizophrenia. Seventy-eight had a family history of psychotic disorder. No differences in PTC taster status were found in UHR participants based upon transition to psychosis status, schizophrenia diagnosis, or family history of schizophrenia. This report indicates that schizophrenia development among UHR participants is not associated with PTC tasting deficits and fails to support previous findings that inability to detect the bitter taste of PTC is a schizophrenia endophenotype.",
author = "Brewer, {Warrick J} and Ashleigh Lin and Moberg, {Paul J} and Gregory Smutzer and Barnaby Nelson and Yung, {Alison R} and Christos Pantelis and McGorry, {Patrick D} and Turetsky, {Bruce I} and Wood, {Stephen J}",
note = "Copyright {\textcopyright} 2012 Elsevier Ireland Ltd. All rights reserved.",
year = "2012",
doi = "10.1016/j.psychres.2012.03.010",
language = "English",
volume = "199",
pages = "8--11",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Phenylthiocarbamide (PTC) perception in ultra-high risk for psychosis participants who develop schizophrenia

T2 - Testing the evidence for an endophenotypic marker

AU - Brewer, Warrick J

AU - Lin, Ashleigh

AU - Moberg, Paul J

AU - Smutzer, Gregory

AU - Nelson, Barnaby

AU - Yung, Alison R

AU - Pantelis, Christos

AU - McGorry, Patrick D

AU - Turetsky, Bruce I

AU - Wood, Stephen J

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2012

Y1 - 2012

N2 - Reports suggesting that schizophrenia participants are more likely to be phenylthiocarbamide (PTC) non-tasters when compared to controls have recently been controversial. If supported, a genetic-based phenotypic variation in PTC taster status is implicated, suggesting a greater illness risk for those participants with recessive alleles for the TAS2R38 receptor. Should PTC insensitivity be a schizophrenia endophenotype, then it would be expected in follow-up of ultra high-risk for psychosis participants who later develop schizophrenia (UHR-S). UHR-S was hypothesised to show reduced PTC sensitivity compared to those who were previously at risk, but did not transition (UHR-NP). PTC perception was assessed in 219 UHR participants at long-term follow-up, of whom 53 had transitioned to psychosis (UHR-P) during the follow-up period. Fifteen of the 219 participants were diagnosed with schizophrenia. Seventy-eight had a family history of psychotic disorder. No differences in PTC taster status were found in UHR participants based upon transition to psychosis status, schizophrenia diagnosis, or family history of schizophrenia. This report indicates that schizophrenia development among UHR participants is not associated with PTC tasting deficits and fails to support previous findings that inability to detect the bitter taste of PTC is a schizophrenia endophenotype.

AB - Reports suggesting that schizophrenia participants are more likely to be phenylthiocarbamide (PTC) non-tasters when compared to controls have recently been controversial. If supported, a genetic-based phenotypic variation in PTC taster status is implicated, suggesting a greater illness risk for those participants with recessive alleles for the TAS2R38 receptor. Should PTC insensitivity be a schizophrenia endophenotype, then it would be expected in follow-up of ultra high-risk for psychosis participants who later develop schizophrenia (UHR-S). UHR-S was hypothesised to show reduced PTC sensitivity compared to those who were previously at risk, but did not transition (UHR-NP). PTC perception was assessed in 219 UHR participants at long-term follow-up, of whom 53 had transitioned to psychosis (UHR-P) during the follow-up period. Fifteen of the 219 participants were diagnosed with schizophrenia. Seventy-eight had a family history of psychotic disorder. No differences in PTC taster status were found in UHR participants based upon transition to psychosis status, schizophrenia diagnosis, or family history of schizophrenia. This report indicates that schizophrenia development among UHR participants is not associated with PTC tasting deficits and fails to support previous findings that inability to detect the bitter taste of PTC is a schizophrenia endophenotype.

U2 - 10.1016/j.psychres.2012.03.010

DO - 10.1016/j.psychres.2012.03.010

M3 - Article

C2 - 22503356

VL - 199

SP - 8

EP - 11

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 1

ER -