Phenotype-environment interactions in genetic syndromes associated with severe or profound intellectual disability

Research output: Contribution to journalReview article

Standard

Phenotype-environment interactions in genetic syndromes associated with severe or profound intellectual disability. / Tunnicliffe, Penny; Oliver, Chris.

In: Research in Developmental Disabilities, Vol. 32, No. 2, 01.03.2011, p. 404-418.

Research output: Contribution to journalReview article

Harvard

APA

Vancouver

Author

Bibtex

@article{92efc92b752b4b51b9f971a33b485a12,
title = "Phenotype-environment interactions in genetic syndromes associated with severe or profound intellectual disability",
abstract = "The research literature notes both biological and operant theories of behavior disorder in individuals with intellectual disabilities. These two theories of genetic predisposition and operant reinforcement remain quite distinct; neither theory on its own is sufficient to explain challenging behavior in genetic syndromes and an integrated approach is required. This literature review integrates the two approaches by exploring how environmental factors can influence problem behavior in genetic syndromes associated with intellectual disability. Particular attention is paid to studies that describe evidence that problem behaviors in syndromes that are considered to be phenotypic are associated with other aspects of an established behavioral phenotype. The review highlights how the study of phenotype-environment interactions within syndromes can promote understanding of the aetiology of problem behaviors both within genetic syndromes and, ultimately, the wider population of individuals with severe intellectual disabilities. The review also evaluates the current status of research and the methods typically employed.Implications for intervention, future research and extending existing causal models of challenging behavior are discussed.",
keywords = "Behavioral phenotypes, Challenging behavior, Intellectual disabilities, Learning disabilities, Phenotype-environment, Syndromes",
author = "Penny Tunnicliffe and Chris Oliver",
year = "2011",
month = mar
day = "1",
doi = "10.1016/j.ridd.2010.12.008",
language = "English",
volume = "32",
pages = "404--418",
journal = "Research in Developmental Disabilities",
issn = "0891-4222",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Phenotype-environment interactions in genetic syndromes associated with severe or profound intellectual disability

AU - Tunnicliffe, Penny

AU - Oliver, Chris

PY - 2011/3/1

Y1 - 2011/3/1

N2 - The research literature notes both biological and operant theories of behavior disorder in individuals with intellectual disabilities. These two theories of genetic predisposition and operant reinforcement remain quite distinct; neither theory on its own is sufficient to explain challenging behavior in genetic syndromes and an integrated approach is required. This literature review integrates the two approaches by exploring how environmental factors can influence problem behavior in genetic syndromes associated with intellectual disability. Particular attention is paid to studies that describe evidence that problem behaviors in syndromes that are considered to be phenotypic are associated with other aspects of an established behavioral phenotype. The review highlights how the study of phenotype-environment interactions within syndromes can promote understanding of the aetiology of problem behaviors both within genetic syndromes and, ultimately, the wider population of individuals with severe intellectual disabilities. The review also evaluates the current status of research and the methods typically employed.Implications for intervention, future research and extending existing causal models of challenging behavior are discussed.

AB - The research literature notes both biological and operant theories of behavior disorder in individuals with intellectual disabilities. These two theories of genetic predisposition and operant reinforcement remain quite distinct; neither theory on its own is sufficient to explain challenging behavior in genetic syndromes and an integrated approach is required. This literature review integrates the two approaches by exploring how environmental factors can influence problem behavior in genetic syndromes associated with intellectual disability. Particular attention is paid to studies that describe evidence that problem behaviors in syndromes that are considered to be phenotypic are associated with other aspects of an established behavioral phenotype. The review highlights how the study of phenotype-environment interactions within syndromes can promote understanding of the aetiology of problem behaviors both within genetic syndromes and, ultimately, the wider population of individuals with severe intellectual disabilities. The review also evaluates the current status of research and the methods typically employed.Implications for intervention, future research and extending existing causal models of challenging behavior are discussed.

KW - Behavioral phenotypes

KW - Challenging behavior

KW - Intellectual disabilities

KW - Learning disabilities

KW - Phenotype-environment

KW - Syndromes

UR - http://www.scopus.com/inward/record.url?scp=79851515076&partnerID=8YFLogxK

U2 - 10.1016/j.ridd.2010.12.008

DO - 10.1016/j.ridd.2010.12.008

M3 - Review article

C2 - 21257289

AN - SCOPUS:79851515076

VL - 32

SP - 404

EP - 418

JO - Research in Developmental Disabilities

JF - Research in Developmental Disabilities

SN - 0891-4222

IS - 2

ER -