Phase-based coordination of hippocampal and neocortical oscillations during human sleep

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Phase-based coordination of hippocampal and neocortical oscillations during human sleep. / Cox, Roy; Rüber, Theodor; Staresina, Bernhard P.; Fell, Juergen.

In: Communications Biology, Vol. 3, No. 1, 176, 01.12.2020.

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@article{28d247d5070244758948c850fcf5b3aa,
title = "Phase-based coordination of hippocampal and neocortical oscillations during human sleep",
abstract = "During sleep, new memories undergo a gradual transfer from hippocampal (HPC) to neocortical (NC) sites. Precisely timed neural oscillations are thought to mediate this sleep-dependent memory consolidation, but exactly how sleep oscillations instantiate the HPC-NC dialog remains elusive. Employing overnight invasive electroencephalography in ten neurosurgical patients, we identified three broad classes of phase-based communication between HPC and lateral temporal NC. First, we observed interregional phase synchrony for non-rapid eye movement (NREM) spindles, and N2 and rapid eye movement (REM) theta activity. Second, we found asymmetrical N3 cross-frequency phase-amplitude coupling between HPC slow oscillations (SOs) and NC activity spanning the delta to high-gamma/ripple bands, but not in the opposite direction. Lastly, N2 theta and NREM spindle synchrony were themselves modulated by HPC SOs. These forms of interregional communication emphasize the role of HPC SOs in the HPC-NC dialog, and may offer a physiological basis for the sleep-dependent reorganization of mnemonic content.",
author = "Roy Cox and Theodor R{\"u}ber and Staresina, {Bernhard P.} and Juergen Fell",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s42003-020-0913-5",
language = "English",
volume = "3",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Phase-based coordination of hippocampal and neocortical oscillations during human sleep

AU - Cox, Roy

AU - Rüber, Theodor

AU - Staresina, Bernhard P.

AU - Fell, Juergen

PY - 2020/12/1

Y1 - 2020/12/1

N2 - During sleep, new memories undergo a gradual transfer from hippocampal (HPC) to neocortical (NC) sites. Precisely timed neural oscillations are thought to mediate this sleep-dependent memory consolidation, but exactly how sleep oscillations instantiate the HPC-NC dialog remains elusive. Employing overnight invasive electroencephalography in ten neurosurgical patients, we identified three broad classes of phase-based communication between HPC and lateral temporal NC. First, we observed interregional phase synchrony for non-rapid eye movement (NREM) spindles, and N2 and rapid eye movement (REM) theta activity. Second, we found asymmetrical N3 cross-frequency phase-amplitude coupling between HPC slow oscillations (SOs) and NC activity spanning the delta to high-gamma/ripple bands, but not in the opposite direction. Lastly, N2 theta and NREM spindle synchrony were themselves modulated by HPC SOs. These forms of interregional communication emphasize the role of HPC SOs in the HPC-NC dialog, and may offer a physiological basis for the sleep-dependent reorganization of mnemonic content.

AB - During sleep, new memories undergo a gradual transfer from hippocampal (HPC) to neocortical (NC) sites. Precisely timed neural oscillations are thought to mediate this sleep-dependent memory consolidation, but exactly how sleep oscillations instantiate the HPC-NC dialog remains elusive. Employing overnight invasive electroencephalography in ten neurosurgical patients, we identified three broad classes of phase-based communication between HPC and lateral temporal NC. First, we observed interregional phase synchrony for non-rapid eye movement (NREM) spindles, and N2 and rapid eye movement (REM) theta activity. Second, we found asymmetrical N3 cross-frequency phase-amplitude coupling between HPC slow oscillations (SOs) and NC activity spanning the delta to high-gamma/ripple bands, but not in the opposite direction. Lastly, N2 theta and NREM spindle synchrony were themselves modulated by HPC SOs. These forms of interregional communication emphasize the role of HPC SOs in the HPC-NC dialog, and may offer a physiological basis for the sleep-dependent reorganization of mnemonic content.

UR - http://www.scopus.com/inward/record.url?scp=85083794234&partnerID=8YFLogxK

U2 - 10.1038/s42003-020-0913-5

DO - 10.1038/s42003-020-0913-5

M3 - Article

C2 - 32313064

AN - SCOPUS:85083794234

VL - 3

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

IS - 1

M1 - 176

ER -