Pharmacology of carbon nanotubes: Toxicokinetics, excretion and tissue accumulation

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • Department of Pharmacology
  • University of Birmingham
  • University of Manchester

Abstract

Carbon nanotubes (CNT) are increasingly being investigated for their use in biomedical applications and nanomedicine. An emergent need for the understanding of their in vivo biodistribution and pharmacokinetics is therefore needed to establish the essential properties and criteria for their further development as targeted CNT delivery systems to specific tissues for diagnostics and therapeutic purposes. Until their biodistribution and toxicoketic profiles are fully understood, their translation into the clinic will be hindered. This review will highlight the important factors affecting the biodistribution and pharmacokinetic profile of CNT and address their toxicokinetics following systemic, pulmonary and dermal exposure.

Details

Original languageEnglish
Pages (from-to)2111-2119
Number of pages9
JournalAdvanced Drug Delivery Reviews
Volume65
Issue number15
Publication statusPublished - 1 Dec 2013

Keywords

  • Biodistribution, Carbon nanotubes, CNT, Functionalisation, Nanotoxicology, Toxicokinetics

ASJC Scopus subject areas