Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation

J C Bailey; M Feelisch; J D Horowitz; M P Frenneaux; M Madhani

doi:10.1016/j.pharmthera.2014.06.009

Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation

J C Bailey, M Feelisch, J D Horowitz, M P Frenneaux, M Madhani

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Abstract

Nitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under hypoxic and acidic conditions to exert vasodilatory effects and confer a variety of other benefits to the cardiovascular system. Abundant research is currently underway to understand the mechanisms involved and define the role of nitrite in health and disease. In this review we discuss the impact of nitrite and dietary nitrate on vascular function and the potential therapeutic role of nitrite in acute heart failure.

Original language	English
Pages (from-to)	303-320
Number of pages	18
Journal	Pharmacology & Therapeutics
Volume	144
Issue number	3
Early online date	30 Jun 2014
DOIs	https://doi.org/10.1016/j.pharmthera.2014.06.009
Publication status	Published - 1 Dec 2014

Keywords

Nitrate
nitrite
Nitric Oxide
vasodilatation
Heart Failure

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10.1016/j.pharmthera.2014.06.009

Bailey_Pharmacology_therapeutic_role_inorganic_nitrate_nitrite_Pharmacology_Therapeutics_2014
NOTICE: this is the author’s version of a work that was accepted for publication in Pharmacology & Therapeutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Pharmacology & Therapeutics, Vol 144, Issue 3, December 2014, DOI: 10.1016/j.pharmthera.2014.06.009. Eligibility for repository checked February 2015
Accepted author manuscript, 487 KBLicence: Other (please specify with Rights Statement)

http://linkinghub.elsevier.com/retrieve/pii/S0163725814001260

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abstract = "Nitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under hypoxic and acidic conditions to exert vasodilatory effects and confer a variety of other benefits to the cardiovascular system. Abundant research is currently underway to understand the mechanisms involved and define the role of nitrite in health and disease. In this review we discuss the impact of nitrite and dietary nitrate on vascular function and the potential therapeutic role of nitrite in acute heart failure.",

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AU - Bailey, J C

AU - Feelisch, M

AU - Horowitz, J D

AU - Frenneaux, M P

AU - Madhani, M

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N2 - Nitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under hypoxic and acidic conditions to exert vasodilatory effects and confer a variety of other benefits to the cardiovascular system. Abundant research is currently underway to understand the mechanisms involved and define the role of nitrite in health and disease. In this review we discuss the impact of nitrite and dietary nitrate on vascular function and the potential therapeutic role of nitrite in acute heart failure.

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KW - Nitrate

KW - nitrite

KW - Nitric Oxide

KW - vasodilatation

KW - Heart Failure

U2 - 10.1016/j.pharmthera.2014.06.009

DO - 10.1016/j.pharmthera.2014.06.009

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JO - Pharmacology & Therapeutics

JF - Pharmacology & Therapeutics

IS - 3

ER -

Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation

Abstract

Keywords

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