Pharmacological comparison of human homomeric 5-HT_3A receptors versus heteromeric 5-HT_3A/3B receptors

CA Brady; Ian Stanford; I Ali; L Lin; Julie Williams; AE Dubin; Anthony Hope; Nicholas Barnes

doi:10.1016/S0028-3908(01)00074-0

Pharmacological comparison of human homomeric 5-HT_3A receptors versus heteromeric 5-HT_3A/3B receptors

CA Brady, Ian Stanford, I Ali, L Lin, Julie Williams, AE Dubin, Anthony Hope, Nicholas Barnes

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Abstract

The present study determined the detailed pharmacological profile of heterologously expressed human (h) homomeric 5-HT3A receptors in direct comparison to heteromeric h5-HT3A/3B receptors. The very minor differences in their respective pharmacological profiles indicates that the 5-HT3B receptor subunit alters, predominantly, the biophysical rather than the pharmacological properties of the 5-HT3 receptor. (C) 2001 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	282-284
Number of pages	3
Journal	Neuropharmacology
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/S0028-3908(01)00074-0
Publication status	Published - 1 Aug 2001

Keywords

5-HT3 receptor
5-HT3B subunit
ligand-gated ion channel
5-HT3A subunit

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10.1016/S0028-3908(01)00074-0

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title = "Pharmacological comparison of human homomeric 5-HT_3A receptors versus heteromeric 5-HT_3A/3B receptors",

abstract = "The present study determined the detailed pharmacological profile of heterologously expressed human (h) homomeric 5-HT3A receptors in direct comparison to heteromeric h5-HT3A/3B receptors. The very minor differences in their respective pharmacological profiles indicates that the 5-HT3B receptor subunit alters, predominantly, the biophysical rather than the pharmacological properties of the 5-HT3 receptor. (C) 2001 Elsevier Science Ltd. All rights reserved.",

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author = "CA Brady and Ian Stanford and I Ali and L Lin and Julie Williams and AE Dubin and Anthony Hope and Nicholas Barnes",

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AU - Brady, CA

AU - Stanford, Ian

AU - Ali, I

AU - Lin, L

AU - Williams, Julie

AU - Dubin, AE

AU - Hope, Anthony

AU - Barnes, Nicholas

PY - 2001/8/1

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AB - The present study determined the detailed pharmacological profile of heterologously expressed human (h) homomeric 5-HT3A receptors in direct comparison to heteromeric h5-HT3A/3B receptors. The very minor differences in their respective pharmacological profiles indicates that the 5-HT3B receptor subunit alters, predominantly, the biophysical rather than the pharmacological properties of the 5-HT3 receptor. (C) 2001 Elsevier Science Ltd. All rights reserved.

KW - 5-HT3 receptor

KW - 5-HT3B subunit

KW - ligand-gated ion channel

KW - 5-HT3A subunit

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IS - 2

ER -

Pharmacological comparison of human homomeric 5-HT_3A receptors versus heteromeric 5-HT_3A/3B receptors

Abstract

Keywords

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