Persistence of self-injury, aggression and property destruction in children and adults with tuberous sclerosis complex
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
- Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, Birmingham B15 2TT, UK.
- University College London, Institute of Cognitive Neuroscience, London, UK; University of Sussex, School of Psychology, UK.
- Division of Child and Adolescent Psychiatry, Department of Psychiatry and Mental Health, University of Cape Town, South Africa.
BACKGROUND: Individuals with tuberous sclerosis complex (TSC) are at increased risk of developing self-injurious behaviour. The persistence of this deleterious behaviour over years is reported in aetiologically heterogeneous samples to be between 60% and 80% but is unknown for TSC.
METHOD: In this study, we determined the 3-year persistence of self-injury in a sample (n = 52) of children (with and without ID) and adults (with ID) with TSC and examined characteristics associated with persistence.
RESULTS: Findings for self-injury were contrasted to those for aggression and property destruction to examine the specificity of results to this behaviour. Self-injury was persistent in 84.6% of those with TSC who showed this behaviour, in contrast to 66.7% both for aggression and destruction. Persistent self-injury was associated with poor self-help skills, greater overactivity/impulsivity and more behavioural indicators of pain. These latter two characteristics were also associated with persistent aggression. No characteristics were associated with persistence of property destruction.
CONCLUSION: These findings suggest that self-injurious behaviours in individuals with TSC, together with aggressive and destructive behaviours, are highly persistent and would benefit from targeted intervention. Poor adaptive skills, overactivity/impulsivity and painful health conditions may differentiate those at most risk for persistent self-injury or aggression.
|Journal||Journal of Intellectual Disability Research|
|Early online date||8 Feb 2018|
|Publication status||E-pub ahead of print - 8 Feb 2018|