Peripherial vascular disease and hypertension: a forgotten association?

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Peripherial vascular disease and hypertension: a forgotten association? / Makin, Andrew; Lip, Gregory; Silverman, Stanley.

In: Journal of Human Hypertension, Vol. 15, No. 7, 01.07.2001, p. 447-454.

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Makin, Andrew ; Lip, Gregory ; Silverman, Stanley. / Peripherial vascular disease and hypertension: a forgotten association?. In: Journal of Human Hypertension. 2001 ; Vol. 15, No. 7. pp. 447-454.

Bibtex

@article{83add08c6050406b83600fe1ea38c0a6,
title = "Peripherial vascular disease and hypertension: a forgotten association?",
abstract = "Peripheral vascular disease (PVD) is associated with a high cardiovascular morbidity and mortality, Intermittent claudication is the most common symptomatic manifestation of PVD, but is also an important predictor of cardiovascular death, increasing it by three-fold, and increasing all-cause mortality by two to five-fold. Hypertension is a common and important risk factor for vascular disorders, including PVD, Of hypertensives at presentation, about 2-5% have intermittent claudication, with this prevalence increasing with age, Similarly, 35-55% of patients with PVD at presentation also have hypertension, Patients who suffer from hypertension with PVD have a greatly increased risk of myocardial infarction and stroke. Apart from the epidemiological associations, hypertension contributes to the pathogenesis of atherosclerosis, the basic underlying pathological process underlying Pvc, Hypertension, in common with PVD, is associated with abnormalities of haemostasis and lipids, leading to an increased atherothrombotic state, Nevertheless, none of the large antihypertensive treatment trials have adequately addressed whether a reduction in blood pressure causes a decrease in PVD incidence. There is therefore an obvious need for such outcome studies, especially since the two conditions are commonly encountered together.",
keywords = "peripheral vascular disease, hypertension, atherosclerosis",
author = "Andrew Makin and Gregory Lip and Stanley Silverman",
year = "2001",
month = jul,
day = "1",
doi = "10.1038/sj.jhh.1001209",
language = "English",
volume = "15",
pages = "447--454",
journal = "Journal of Human Hypertension",
issn = "0950-9240",
publisher = "Nature Publishing Group",
number = "7",

}

RIS

TY - JOUR

T1 - Peripherial vascular disease and hypertension: a forgotten association?

AU - Makin, Andrew

AU - Lip, Gregory

AU - Silverman, Stanley

PY - 2001/7/1

Y1 - 2001/7/1

N2 - Peripheral vascular disease (PVD) is associated with a high cardiovascular morbidity and mortality, Intermittent claudication is the most common symptomatic manifestation of PVD, but is also an important predictor of cardiovascular death, increasing it by three-fold, and increasing all-cause mortality by two to five-fold. Hypertension is a common and important risk factor for vascular disorders, including PVD, Of hypertensives at presentation, about 2-5% have intermittent claudication, with this prevalence increasing with age, Similarly, 35-55% of patients with PVD at presentation also have hypertension, Patients who suffer from hypertension with PVD have a greatly increased risk of myocardial infarction and stroke. Apart from the epidemiological associations, hypertension contributes to the pathogenesis of atherosclerosis, the basic underlying pathological process underlying Pvc, Hypertension, in common with PVD, is associated with abnormalities of haemostasis and lipids, leading to an increased atherothrombotic state, Nevertheless, none of the large antihypertensive treatment trials have adequately addressed whether a reduction in blood pressure causes a decrease in PVD incidence. There is therefore an obvious need for such outcome studies, especially since the two conditions are commonly encountered together.

AB - Peripheral vascular disease (PVD) is associated with a high cardiovascular morbidity and mortality, Intermittent claudication is the most common symptomatic manifestation of PVD, but is also an important predictor of cardiovascular death, increasing it by three-fold, and increasing all-cause mortality by two to five-fold. Hypertension is a common and important risk factor for vascular disorders, including PVD, Of hypertensives at presentation, about 2-5% have intermittent claudication, with this prevalence increasing with age, Similarly, 35-55% of patients with PVD at presentation also have hypertension, Patients who suffer from hypertension with PVD have a greatly increased risk of myocardial infarction and stroke. Apart from the epidemiological associations, hypertension contributes to the pathogenesis of atherosclerosis, the basic underlying pathological process underlying Pvc, Hypertension, in common with PVD, is associated with abnormalities of haemostasis and lipids, leading to an increased atherothrombotic state, Nevertheless, none of the large antihypertensive treatment trials have adequately addressed whether a reduction in blood pressure causes a decrease in PVD incidence. There is therefore an obvious need for such outcome studies, especially since the two conditions are commonly encountered together.

KW - peripheral vascular disease

KW - hypertension

KW - atherosclerosis

UR - http://www.scopus.com/inward/record.url?scp=0034944453&partnerID=8YFLogxK

U2 - 10.1038/sj.jhh.1001209

DO - 10.1038/sj.jhh.1001209

M3 - Review article

C2 - 11464253

VL - 15

SP - 447

EP - 454

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

IS - 7

ER -