Periodontitis prevalence and serum antibody reactivity to periodontal bacteria in primary Sjögren’s syndrome: a pilot study

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@article{012db5f7a3dd4451ab0f97449c2435d0,
title = "Periodontitis prevalence and serum antibody reactivity to periodontal bacteria in primary Sj{\"o}gren{\textquoteright}s syndrome: a pilot study",
abstract = "Aims: The aims of this study were as follows: (i) To assessthe prevalence of periodontitis among patients with primary Sj{\"o}gren's syndrome(pSS) and comparator groups of patients with rheumatoid arthritis (RA) andosteoarthritis (OA). (ii) To perform a pilot study to compare serum antibodyresponses to 10 oral/periodontal bacteria in these patient groups and ahistorical comparator group of patients with periodontitis.Materials and Methods: Standard clinical periodontal assessments were performedon 39 pSS, 36 RA and 23 OA patients and “In‐house” antibody ELISAs for serumantibodies against 10 oral/periodontal bacteria were performed in these groups.Results: Forty‐six percent of the pSS group, 64% of the RA group and 48% of theOA group had moderate/severe periodontitis. These frequencies did not reachstatistical significance between groups. Raised antibody levels to Prevotelladenticola were found in the pSS, RA and periodontitis groups compared to the OAgroup. Significant between group differences were seen for Aggregatibacteractinomycetemcomitans, Prevotella intermedia and Campylobacter showae. None ofthese differences were specifically associated with pSS.Conclusion: This study showed no increase in periodontitis in pSS patients.Although the P. denticola data are of interest, identifying bacterialtriggering factors for pSS will likely require alternative strategies includingmodern techniques such as microbiome analysis.",
keywords = "bacterial reactivity, periodontitis, Sjogren{\textquoteright}s",
author = "Bozo Lugonja and Lorraine Yeo and Michael Milward and Diana Smith and Thomas Dietrich and Iain Chapple and Saaeha Rauz and Geraint Williams and Francesca Barone and {De Pablo}, Paola and Christopher Buckley and John Hamburger and Andrea Richards and Ana Poveda and Dagmar Scheel-Toellner and S Bowman",
note = "This article is protected by copyright. All rights reserved.",
year = "2016",
month = jan,
doi = "10.1111/jcpe.12485",
language = "English",
volume = "43",
pages = "26--33",
journal = "Journal of Clinical Periodontology",
issn = "0303-6979",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Periodontitis prevalence and serum antibody reactivity to periodontal bacteria in primary Sjögren’s syndrome

T2 - a pilot study

AU - Lugonja, Bozo

AU - Yeo, Lorraine

AU - Milward, Michael

AU - Smith, Diana

AU - Dietrich, Thomas

AU - Chapple, Iain

AU - Rauz, Saaeha

AU - Williams, Geraint

AU - Barone, Francesca

AU - De Pablo, Paola

AU - Buckley, Christopher

AU - Hamburger, John

AU - Richards, Andrea

AU - Poveda, Ana

AU - Scheel-Toellner, Dagmar

AU - Bowman, S

N1 - This article is protected by copyright. All rights reserved.

PY - 2016/1

Y1 - 2016/1

N2 - Aims: The aims of this study were as follows: (i) To assessthe prevalence of periodontitis among patients with primary Sjögren's syndrome(pSS) and comparator groups of patients with rheumatoid arthritis (RA) andosteoarthritis (OA). (ii) To perform a pilot study to compare serum antibodyresponses to 10 oral/periodontal bacteria in these patient groups and ahistorical comparator group of patients with periodontitis.Materials and Methods: Standard clinical periodontal assessments were performedon 39 pSS, 36 RA and 23 OA patients and “In‐house” antibody ELISAs for serumantibodies against 10 oral/periodontal bacteria were performed in these groups.Results: Forty‐six percent of the pSS group, 64% of the RA group and 48% of theOA group had moderate/severe periodontitis. These frequencies did not reachstatistical significance between groups. Raised antibody levels to Prevotelladenticola were found in the pSS, RA and periodontitis groups compared to the OAgroup. Significant between group differences were seen for Aggregatibacteractinomycetemcomitans, Prevotella intermedia and Campylobacter showae. None ofthese differences were specifically associated with pSS.Conclusion: This study showed no increase in periodontitis in pSS patients.Although the P. denticola data are of interest, identifying bacterialtriggering factors for pSS will likely require alternative strategies includingmodern techniques such as microbiome analysis.

AB - Aims: The aims of this study were as follows: (i) To assessthe prevalence of periodontitis among patients with primary Sjögren's syndrome(pSS) and comparator groups of patients with rheumatoid arthritis (RA) andosteoarthritis (OA). (ii) To perform a pilot study to compare serum antibodyresponses to 10 oral/periodontal bacteria in these patient groups and ahistorical comparator group of patients with periodontitis.Materials and Methods: Standard clinical periodontal assessments were performedon 39 pSS, 36 RA and 23 OA patients and “In‐house” antibody ELISAs for serumantibodies against 10 oral/periodontal bacteria were performed in these groups.Results: Forty‐six percent of the pSS group, 64% of the RA group and 48% of theOA group had moderate/severe periodontitis. These frequencies did not reachstatistical significance between groups. Raised antibody levels to Prevotelladenticola were found in the pSS, RA and periodontitis groups compared to the OAgroup. Significant between group differences were seen for Aggregatibacteractinomycetemcomitans, Prevotella intermedia and Campylobacter showae. None ofthese differences were specifically associated with pSS.Conclusion: This study showed no increase in periodontitis in pSS patients.Although the P. denticola data are of interest, identifying bacterialtriggering factors for pSS will likely require alternative strategies includingmodern techniques such as microbiome analysis.

KW - bacterial reactivity

KW - periodontitis

KW - Sjogren’s

U2 - 10.1111/jcpe.12485

DO - 10.1111/jcpe.12485

M3 - Article

C2 - 26646777

VL - 43

SP - 26

EP - 33

JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

SN - 0303-6979

IS - 1

ER -