Peptide aptamers: novel coatings for orthopaedic implants

Micah Kelly; Richard Williams; Anuriti Aojula; Jenna O'neill; Zuzanna Trzińscka; Liam Grover; Robert A.h. Scott; Anna F.a. Peacock; Ann Logan; Artemis Stamboulis; Felicity De Cogan

doi:10.1016/j.msec.2015.04.021

Peptide aptamers: novel coatings for orthopaedic implants

Micah Kelly, Richard Williams, Anuriti Aojula, Jenna O'neill, Zuzanna Trzińscka, Liam Grover, Robert A.h. Scott, Anna F.a. Peacock, Ann Logan, Artemis Stamboulis, Felicity De Cogan

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Abstract

Current processes for coating titanium implants with ceramics involve very high energy techniques with associated high cost and disadvantages such as heterogeneity of the coatings, phase transformations and inability to coat complex structures. In order to address the above problems, we propose a biomimetic hydroxyapatite coating process with the use of peptides that can bind both on titanium surfaces and hydroxyapatite. The peptides enabled homogeneous coating of a titanium surface with hydroxyapatite. The hydroxyapatite–peptide sandwich coating showed no adverse effects on cell number or collagen deposition. This makes the sandwich coated titanium a good candidate for titanium implants used in orthopaedics and dentistry.

Original language	English
Pages (from-to)	84-93
Journal	Materials Science and Engineering C
Volume	54
Early online date	21 Apr 2015
DOIs	https://doi.org/10.1016/j.msec.2015.04.021
Publication status	Published - 1 Sept 2015

Keywords

Biomimetic peptide
Peptide coating
Titanium coating
Hydroxyapatite coating
Implant coating

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10.1016/j.msec.2015.04.021Licence: None: All rights reserved

Kelly_et_al_Peptide_aptamers_Materials_Science_Engineering_C_2015
NOTICE: this is the author’s version of a work that was accepted for publication. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published as Micah Kelly, Richard Williams, Anuriti Aojula, Jenna O’Neill, Zuzanna Trzi´nscka, Liam Grover, Robert Scott, Anna F.A. Peacock, Ann Logan, Artemis Stamboulis, Felicity de Cogan, Peptide Aptamers: Novel Coatings for Orthopaedic Implants, Materials Science & Engineering C (2015), doi: 10.1016/j.msec.2015.04.021
Accepted author manuscript, 1.08 MBLicence: None: All rights reserved

https://www.sciencedirect.com/science/article/pii/S0928493115300242Licence: None: All rights reserved

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title = "Peptide aptamers: novel coatings for orthopaedic implants",

abstract = "Current processes for coating titanium implants with ceramics involve very high energy techniques with associated high cost and disadvantages such as heterogeneity of the coatings, phase transformations and inability to coat complex structures. In order to address the above problems, we propose a biomimetic hydroxyapatite coating process with the use of peptides that can bind both on titanium surfaces and hydroxyapatite. The peptides enabled homogeneous coating of a titanium surface with hydroxyapatite. The hydroxyapatite–peptide sandwich coating showed no adverse effects on cell number or collagen deposition. This makes the sandwich coated titanium a good candidate for titanium implants used in orthopaedics and dentistry.",

keywords = "Biomimetic peptide, Peptide coating, Titanium coating, Hydroxyapatite coating, Implant coating",

author = "Micah Kelly and Richard Williams and Anuriti Aojula and Jenna O'neill and Zuzanna Trzi{\'n}scka and Liam Grover and Scott, {Robert A.h.} and Peacock, {Anna F.a.} and Ann Logan and Artemis Stamboulis and {De Cogan}, Felicity",

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doi = "10.1016/j.msec.2015.04.021",

language = "English",

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TY - JOUR

T1 - Peptide aptamers

T2 - novel coatings for orthopaedic implants

AU - Kelly, Micah

AU - Williams, Richard

AU - Aojula, Anuriti

AU - O'neill, Jenna

AU - Trzińscka, Zuzanna

AU - Grover, Liam

AU - Scott, Robert A.h.

AU - Peacock, Anna F.a.

AU - Logan, Ann

AU - Stamboulis, Artemis

AU - De Cogan, Felicity

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Current processes for coating titanium implants with ceramics involve very high energy techniques with associated high cost and disadvantages such as heterogeneity of the coatings, phase transformations and inability to coat complex structures. In order to address the above problems, we propose a biomimetic hydroxyapatite coating process with the use of peptides that can bind both on titanium surfaces and hydroxyapatite. The peptides enabled homogeneous coating of a titanium surface with hydroxyapatite. The hydroxyapatite–peptide sandwich coating showed no adverse effects on cell number or collagen deposition. This makes the sandwich coated titanium a good candidate for titanium implants used in orthopaedics and dentistry.

AB - Current processes for coating titanium implants with ceramics involve very high energy techniques with associated high cost and disadvantages such as heterogeneity of the coatings, phase transformations and inability to coat complex structures. In order to address the above problems, we propose a biomimetic hydroxyapatite coating process with the use of peptides that can bind both on titanium surfaces and hydroxyapatite. The peptides enabled homogeneous coating of a titanium surface with hydroxyapatite. The hydroxyapatite–peptide sandwich coating showed no adverse effects on cell number or collagen deposition. This makes the sandwich coated titanium a good candidate for titanium implants used in orthopaedics and dentistry.

KW - Biomimetic peptide

KW - Peptide coating

KW - Titanium coating

KW - Hydroxyapatite coating

KW - Implant coating

U2 - 10.1016/j.msec.2015.04.021

DO - 10.1016/j.msec.2015.04.021

M3 - Article

SN - 0928-4931

VL - 54

SP - 84

EP - 93

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

ER -

Peptide aptamers: novel coatings for orthopaedic implants

Abstract

Keywords

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