Penetration of sub-micron particles into dentinal tubules using ultrasonic cavitation

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@article{6703d538354c467c824f932310314d47,
title = "Penetration of sub-micron particles into dentinal tubules using ultrasonic cavitation",
abstract = "ObjectivesFunctionalised silica sub-micron particles are being investigated as a method of delivering antimicrobials and remineralisation agents into dentinal tubules. However, their methods of application are not optimised, resulting in shallow penetration and aggregation. The aim of this study is to investigate the impact of cavitation occurring around ultrasonic scalers for enhancing particle penetration into dentinal tubules.MethodsDentine slices were prepared from premolar teeth. Silica sub-micron particles were prepared in water or acetone. Cavitation from an ultrasonic scaler (Satelec P5 Newtron, Acteon, France) was applied to dentine slices immersed inside the sub-micron particle solutions. Samples were imaged with scanning electron microscopy (SEM) to assess tubule occlusion and particle penetration.ResultsQualitative observations of SEM images showed some tubule occlusion. The particles could penetrate inside the tubules up to 60 μm when there was no cavitation and up to ∼180 μm when there was cavitation.ConclusionsThe cavitation bubbles produced from an ultrasonic scaler may be used to deliver sub-micron particles into dentine. This method has the potential to deliver such particles deeper into the dentinal tubules.Clinical significanceCavitation from a clinical ultrasonic scaler may enhance penetration of sub-micron particles into dentinal tubules. This can aid in the development of novel methods for delivering therapeutic clinical materials for hypersensitivity relief and treatment of dentinal caries.",
keywords = "Dental nanomaterials , Sub-micron particles , Tubule occlusion , Ultrasonic scalers , Cavitation , Electron microscopy",
author = "Nina Vyas and Rachel Sammons and Zoe Pikramenou and William Palin and Hamid Dehghani and Anthony Walmsley",
year = "2017",
month = jan,
doi = "10.1016/j.jdent.2016.11.006",
language = "English",
volume = "56",
pages = "112--120",
journal = "Journal of Dentistry",
issn = "0300-5712",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Penetration of sub-micron particles into dentinal tubules using ultrasonic cavitation

AU - Vyas, Nina

AU - Sammons, Rachel

AU - Pikramenou, Zoe

AU - Palin, William

AU - Dehghani, Hamid

AU - Walmsley, Anthony

PY - 2017/1

Y1 - 2017/1

N2 - ObjectivesFunctionalised silica sub-micron particles are being investigated as a method of delivering antimicrobials and remineralisation agents into dentinal tubules. However, their methods of application are not optimised, resulting in shallow penetration and aggregation. The aim of this study is to investigate the impact of cavitation occurring around ultrasonic scalers for enhancing particle penetration into dentinal tubules.MethodsDentine slices were prepared from premolar teeth. Silica sub-micron particles were prepared in water or acetone. Cavitation from an ultrasonic scaler (Satelec P5 Newtron, Acteon, France) was applied to dentine slices immersed inside the sub-micron particle solutions. Samples were imaged with scanning electron microscopy (SEM) to assess tubule occlusion and particle penetration.ResultsQualitative observations of SEM images showed some tubule occlusion. The particles could penetrate inside the tubules up to 60 μm when there was no cavitation and up to ∼180 μm when there was cavitation.ConclusionsThe cavitation bubbles produced from an ultrasonic scaler may be used to deliver sub-micron particles into dentine. This method has the potential to deliver such particles deeper into the dentinal tubules.Clinical significanceCavitation from a clinical ultrasonic scaler may enhance penetration of sub-micron particles into dentinal tubules. This can aid in the development of novel methods for delivering therapeutic clinical materials for hypersensitivity relief and treatment of dentinal caries.

AB - ObjectivesFunctionalised silica sub-micron particles are being investigated as a method of delivering antimicrobials and remineralisation agents into dentinal tubules. However, their methods of application are not optimised, resulting in shallow penetration and aggregation. The aim of this study is to investigate the impact of cavitation occurring around ultrasonic scalers for enhancing particle penetration into dentinal tubules.MethodsDentine slices were prepared from premolar teeth. Silica sub-micron particles were prepared in water or acetone. Cavitation from an ultrasonic scaler (Satelec P5 Newtron, Acteon, France) was applied to dentine slices immersed inside the sub-micron particle solutions. Samples were imaged with scanning electron microscopy (SEM) to assess tubule occlusion and particle penetration.ResultsQualitative observations of SEM images showed some tubule occlusion. The particles could penetrate inside the tubules up to 60 μm when there was no cavitation and up to ∼180 μm when there was cavitation.ConclusionsThe cavitation bubbles produced from an ultrasonic scaler may be used to deliver sub-micron particles into dentine. This method has the potential to deliver such particles deeper into the dentinal tubules.Clinical significanceCavitation from a clinical ultrasonic scaler may enhance penetration of sub-micron particles into dentinal tubules. This can aid in the development of novel methods for delivering therapeutic clinical materials for hypersensitivity relief and treatment of dentinal caries.

KW - Dental nanomaterials

KW - Sub-micron particles

KW - Tubule occlusion

KW - Ultrasonic scalers

KW - Cavitation

KW - Electron microscopy

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85006827081&partnerID=MN8TOARS

U2 - 10.1016/j.jdent.2016.11.006

DO - 10.1016/j.jdent.2016.11.006

M3 - Article

VL - 56

SP - 112

EP - 120

JO - Journal of Dentistry

JF - Journal of Dentistry

SN - 0300-5712

ER -