PDGFR{alpha}-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches

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PDGFR{alpha}-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches. / Jenkinson, William; Rossi, Simona; Parnell, Sonia; Jenkinson, Eric; Anderson, Graham.

In: Blood, Vol. 109, No. 3, 05.10.2006, p. 954-60.

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@article{88ed3c3c08ac4a55a1439dc751cc1895,
title = "PDGFR{alpha}-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches",
abstract = "The thymus provides a specialized site for the production of T cells capable of recognizing foreign antigens in the context of self-major histocompatibility complex (MHC) molecules. During development, the thymus arises from an epithelial rudiment containing bipotent progenitors that differentiate into distinct cortical and medullary epithelial cells to regulate the maturation and selection of self-tolerant CD4(+) and CD8(+) T cells. In addition to their differentiation, thymic epithelial cells undergo cellular expansion to ensure that sufficient intrathymic cellular niches are available to support the large number of immature thymocytes required to form a self-tolerant T-cell pool. Thus, intrathymic T-cell production is intimately linked to the formation and availability of niches within thymic microenvironments. Here, we show the increase in intrathymic niches caused by the proliferation of the epithelium in the developing thymus is temporally regulated, and correlates with the presence of a population of fetal thymic mesenchyme defined by platelet derived growth factor receptor alpha (PDGFR alpha) expression. Depletion of PDGFR alpha(+) mesenchyme from embryonic thymi prior to their transplantation to ectopic sites results in the formation of functional yet hypoplastic thymic tissue. In summary, we highlight a specialized role for PDGFR alpha+ fetal mesenchyme in the thymus by determining availability of thymic niches through the regulation of thymic epithelial proliferation.",
author = "William Jenkinson and Simona Rossi and Sonia Parnell and Eric Jenkinson and Graham Anderson",
year = "2006",
month = oct,
day = "5",
doi = "10.1182/blood-2006-05-023143",
language = "English",
volume = "109",
pages = "954--60",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "3",

}

RIS

TY - JOUR

T1 - PDGFR{alpha}-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches

AU - Jenkinson, William

AU - Rossi, Simona

AU - Parnell, Sonia

AU - Jenkinson, Eric

AU - Anderson, Graham

PY - 2006/10/5

Y1 - 2006/10/5

N2 - The thymus provides a specialized site for the production of T cells capable of recognizing foreign antigens in the context of self-major histocompatibility complex (MHC) molecules. During development, the thymus arises from an epithelial rudiment containing bipotent progenitors that differentiate into distinct cortical and medullary epithelial cells to regulate the maturation and selection of self-tolerant CD4(+) and CD8(+) T cells. In addition to their differentiation, thymic epithelial cells undergo cellular expansion to ensure that sufficient intrathymic cellular niches are available to support the large number of immature thymocytes required to form a self-tolerant T-cell pool. Thus, intrathymic T-cell production is intimately linked to the formation and availability of niches within thymic microenvironments. Here, we show the increase in intrathymic niches caused by the proliferation of the epithelium in the developing thymus is temporally regulated, and correlates with the presence of a population of fetal thymic mesenchyme defined by platelet derived growth factor receptor alpha (PDGFR alpha) expression. Depletion of PDGFR alpha(+) mesenchyme from embryonic thymi prior to their transplantation to ectopic sites results in the formation of functional yet hypoplastic thymic tissue. In summary, we highlight a specialized role for PDGFR alpha+ fetal mesenchyme in the thymus by determining availability of thymic niches through the regulation of thymic epithelial proliferation.

AB - The thymus provides a specialized site for the production of T cells capable of recognizing foreign antigens in the context of self-major histocompatibility complex (MHC) molecules. During development, the thymus arises from an epithelial rudiment containing bipotent progenitors that differentiate into distinct cortical and medullary epithelial cells to regulate the maturation and selection of self-tolerant CD4(+) and CD8(+) T cells. In addition to their differentiation, thymic epithelial cells undergo cellular expansion to ensure that sufficient intrathymic cellular niches are available to support the large number of immature thymocytes required to form a self-tolerant T-cell pool. Thus, intrathymic T-cell production is intimately linked to the formation and availability of niches within thymic microenvironments. Here, we show the increase in intrathymic niches caused by the proliferation of the epithelium in the developing thymus is temporally regulated, and correlates with the presence of a population of fetal thymic mesenchyme defined by platelet derived growth factor receptor alpha (PDGFR alpha) expression. Depletion of PDGFR alpha(+) mesenchyme from embryonic thymi prior to their transplantation to ectopic sites results in the formation of functional yet hypoplastic thymic tissue. In summary, we highlight a specialized role for PDGFR alpha+ fetal mesenchyme in the thymus by determining availability of thymic niches through the regulation of thymic epithelial proliferation.

UR - http://www.scopus.com/inward/record.url?scp=33846867492&partnerID=8YFLogxK

U2 - 10.1182/blood-2006-05-023143

DO - 10.1182/blood-2006-05-023143

M3 - Article

C2 - 17008543

VL - 109

SP - 954

EP - 960

JO - Blood

JF - Blood

SN - 0006-4971

IS - 3

ER -