Patterns of single-neuron activity during associative recognition memory in the human medial temporal lobe

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Patterns of single-neuron activity during associative recognition memory in the human medial temporal lobe. / Derner, M.; Dehnen, G.; Chaieb, L.; Reber, T. P.; Borger, V.; Surges, R.; Staresina, B. P.; Mormann, F.; Fell, J.

In: NeuroImage, Vol. 221, 117214, 01.11.2020.

Research output: Contribution to journalArticlepeer-review

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Derner, M., Dehnen, G., Chaieb, L., Reber, T. P., Borger, V., Surges, R., Staresina, B. P., Mormann, F., & Fell, J. (2020). Patterns of single-neuron activity during associative recognition memory in the human medial temporal lobe. NeuroImage, 221, [117214]. https://doi.org/10.1016/j.neuroimage.2020.117214

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Derner, M. ; Dehnen, G. ; Chaieb, L. ; Reber, T. P. ; Borger, V. ; Surges, R. ; Staresina, B. P. ; Mormann, F. ; Fell, J. / Patterns of single-neuron activity during associative recognition memory in the human medial temporal lobe. In: NeuroImage. 2020 ; Vol. 221.

Bibtex

@article{2f6aec5646ff4673817c539dcc268bc1,
title = "Patterns of single-neuron activity during associative recognition memory in the human medial temporal lobe",
abstract = "Electrophysiological activity in medial temporal lobe (MTL) structures is pivotal for declarative long-term memory. Single-neuron and microcircuit findings capitalizing on human microwire recordings from the medial temporal lobe are still fragmentary. In particular, it is an open question whether identical or different groups of neurons participate in different memory functions. Here, we investigated category-specific responses in the human MTL based on single-neuron recordings in presurgical epilepsy patients performing an associative long-term memory task. Additionally, auditory beat stimuli were presented during encoding and retrieval to modulate memory performance. We describe the proportion of neurons in amygdala, entorhinal cortex, hippocampus and parahippocampal cortex belonging to different response classes. These entail neurons coding stimulus-familiarity, neurons coding successful item memory, and neurons coding associated source memory, as well as the overlap between these classes. As major results we demonstrate that neurons responding to stimulus familiarity (old/new effect) can be identified in the MTL even when using previously known rather than entirely novel stimulus material (words). We observed a significant overlap between familiarity-related neurons and neurons coding item retrieval (remembered/forgotten effect). The largest fraction of familiarity-related neurons was found in the parahippocampal cortex, and a considerable fraction of all parahippocampal neurons was related to successful item retrieval. Neurons related to successful source retrieval were different from the neurons coding the associated information. Most importantly, there was no overlap between neurons coding item memory and those coding associated source memory strongly suggesting that these functions are facilitated by different sets of neurons.",
keywords = "Familiarity, Item recognition, Long-term memory, Microwire recordings, Recollection, Source recognition",
author = "M. Derner and G. Dehnen and L. Chaieb and Reber, {T. P.} and V. Borger and R. Surges and Staresina, {B. P.} and F. Mormann and J. Fell",
year = "2020",
month = nov,
day = "1",
doi = "10.1016/j.neuroimage.2020.117214",
language = "English",
volume = "221",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Patterns of single-neuron activity during associative recognition memory in the human medial temporal lobe

AU - Derner, M.

AU - Dehnen, G.

AU - Chaieb, L.

AU - Reber, T. P.

AU - Borger, V.

AU - Surges, R.

AU - Staresina, B. P.

AU - Mormann, F.

AU - Fell, J.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Electrophysiological activity in medial temporal lobe (MTL) structures is pivotal for declarative long-term memory. Single-neuron and microcircuit findings capitalizing on human microwire recordings from the medial temporal lobe are still fragmentary. In particular, it is an open question whether identical or different groups of neurons participate in different memory functions. Here, we investigated category-specific responses in the human MTL based on single-neuron recordings in presurgical epilepsy patients performing an associative long-term memory task. Additionally, auditory beat stimuli were presented during encoding and retrieval to modulate memory performance. We describe the proportion of neurons in amygdala, entorhinal cortex, hippocampus and parahippocampal cortex belonging to different response classes. These entail neurons coding stimulus-familiarity, neurons coding successful item memory, and neurons coding associated source memory, as well as the overlap between these classes. As major results we demonstrate that neurons responding to stimulus familiarity (old/new effect) can be identified in the MTL even when using previously known rather than entirely novel stimulus material (words). We observed a significant overlap between familiarity-related neurons and neurons coding item retrieval (remembered/forgotten effect). The largest fraction of familiarity-related neurons was found in the parahippocampal cortex, and a considerable fraction of all parahippocampal neurons was related to successful item retrieval. Neurons related to successful source retrieval were different from the neurons coding the associated information. Most importantly, there was no overlap between neurons coding item memory and those coding associated source memory strongly suggesting that these functions are facilitated by different sets of neurons.

AB - Electrophysiological activity in medial temporal lobe (MTL) structures is pivotal for declarative long-term memory. Single-neuron and microcircuit findings capitalizing on human microwire recordings from the medial temporal lobe are still fragmentary. In particular, it is an open question whether identical or different groups of neurons participate in different memory functions. Here, we investigated category-specific responses in the human MTL based on single-neuron recordings in presurgical epilepsy patients performing an associative long-term memory task. Additionally, auditory beat stimuli were presented during encoding and retrieval to modulate memory performance. We describe the proportion of neurons in amygdala, entorhinal cortex, hippocampus and parahippocampal cortex belonging to different response classes. These entail neurons coding stimulus-familiarity, neurons coding successful item memory, and neurons coding associated source memory, as well as the overlap between these classes. As major results we demonstrate that neurons responding to stimulus familiarity (old/new effect) can be identified in the MTL even when using previously known rather than entirely novel stimulus material (words). We observed a significant overlap between familiarity-related neurons and neurons coding item retrieval (remembered/forgotten effect). The largest fraction of familiarity-related neurons was found in the parahippocampal cortex, and a considerable fraction of all parahippocampal neurons was related to successful item retrieval. Neurons related to successful source retrieval were different from the neurons coding the associated information. Most importantly, there was no overlap between neurons coding item memory and those coding associated source memory strongly suggesting that these functions are facilitated by different sets of neurons.

KW - Familiarity

KW - Item recognition

KW - Long-term memory

KW - Microwire recordings

KW - Recollection

KW - Source recognition

UR - http://www.scopus.com/inward/record.url?scp=85089154579&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2020.117214

DO - 10.1016/j.neuroimage.2020.117214

M3 - Article

AN - SCOPUS:85089154579

VL - 221

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

M1 - 117214

ER -