Patterns of lymph node recurrence in adrenocortical carcinoma: possible implications for primary surgical treatment

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Patterns of lymph node recurrence in adrenocortical carcinoma : possible implications for primary surgical treatment. / Reibetanz, Joachim; Rinn, Britta; Kunz, Andreas S.; Flemming, Sven; Ronchi, Cristina; Kroiss, Matthias; Deutschbein, Timo; Pulzer, Alina; Hahner, Stefanie; Kocot, Arkadius; Germer, Christoph-Thomas; Fassnacht, Martin; Jurowich, Christian.

In: Annals of Surgical Oncology, Vol. 26, No. 2, 15.02.2019, p. 531–538.

Research output: Contribution to journalArticlepeer-review

Harvard

Reibetanz, J, Rinn, B, Kunz, AS, Flemming, S, Ronchi, C, Kroiss, M, Deutschbein, T, Pulzer, A, Hahner, S, Kocot, A, Germer, C-T, Fassnacht, M & Jurowich, C 2019, 'Patterns of lymph node recurrence in adrenocortical carcinoma: possible implications for primary surgical treatment', Annals of Surgical Oncology, vol. 26, no. 2, pp. 531–538. https://doi.org/10.1245/s10434-018-6999-z

APA

Reibetanz, J., Rinn, B., Kunz, A. S., Flemming, S., Ronchi, C., Kroiss, M., Deutschbein, T., Pulzer, A., Hahner, S., Kocot, A., Germer, C-T., Fassnacht, M., & Jurowich, C. (2019). Patterns of lymph node recurrence in adrenocortical carcinoma: possible implications for primary surgical treatment. Annals of Surgical Oncology, 26(2), 531–538. https://doi.org/10.1245/s10434-018-6999-z

Vancouver

Author

Reibetanz, Joachim ; Rinn, Britta ; Kunz, Andreas S. ; Flemming, Sven ; Ronchi, Cristina ; Kroiss, Matthias ; Deutschbein, Timo ; Pulzer, Alina ; Hahner, Stefanie ; Kocot, Arkadius ; Germer, Christoph-Thomas ; Fassnacht, Martin ; Jurowich, Christian. / Patterns of lymph node recurrence in adrenocortical carcinoma : possible implications for primary surgical treatment. In: Annals of Surgical Oncology. 2019 ; Vol. 26, No. 2. pp. 531–538.

Bibtex

@article{61f0a2faef10460c985507418ab222c5,
title = "Patterns of lymph node recurrence in adrenocortical carcinoma: possible implications for primary surgical treatment",
abstract = "Background: In the surgical treatment of adrenocortical carcinoma (ACC), lymphadenectomy may improve oncologic outcome. However, patterns of metastatic lymphatic spread in ACC are unknown.Methods: Clinical data of patients included in the European Network for the Study of Adrenal Tumors (ENSAT) registry were retrospectively reviewed. Inclusion criteria were: nonmetastatic ACC, complete resection of the primary tumor, a disease-free time of > 3 months, and lymph node metastases as the first disease relapse. The retroperitoneal lymphatic drainage area was evaluated by using follow-up imaging.Results: Of 971 patients from the ENSAT registry, 56 patients were included. In left-sided ACC (n = 36), lymphatic recurrence was detected in the left renal hilum (50%), in the perirenal fat tissue cranial to the renal hilum (ventral, 47%; dorsal, 55%), para-aortic (47%), interaorto-caval (22%), and/or in the perirenal fat tissue caudal to the renal hilum (ventral, 20%; dorsal, 17%). In right-sided ACC (n = 20), lymph node metastases were detected in the perirenal fat tissue cranial to the renal hilum (dorsal, 55%; ventral, 45%), interaorto-caval (35%), in the area of the right renal artery (10%), and/or paracaval (15%). Patients with right-sided ACC showed left-paraaortic lymph node recurrences in 10% of cases.Conclusion: Metastatic lymphatic spread appears to be more extensive than previously thought. The distribution pattern of lymph node metastases described in our study could be used as a guide for a more extended lymph node dissection.",
author = "Joachim Reibetanz and Britta Rinn and Kunz, {Andreas S.} and Sven Flemming and Cristina Ronchi and Matthias Kroiss and Timo Deutschbein and Alina Pulzer and Stefanie Hahner and Arkadius Kocot and Christoph-Thomas Germer and Martin Fassnacht and Christian Jurowich",
year = "2019",
month = feb,
day = "15",
doi = "10.1245/s10434-018-6999-z",
language = "English",
volume = "26",
pages = "531–538",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Patterns of lymph node recurrence in adrenocortical carcinoma

T2 - possible implications for primary surgical treatment

AU - Reibetanz, Joachim

AU - Rinn, Britta

AU - Kunz, Andreas S.

AU - Flemming, Sven

AU - Ronchi, Cristina

AU - Kroiss, Matthias

AU - Deutschbein, Timo

AU - Pulzer, Alina

AU - Hahner, Stefanie

AU - Kocot, Arkadius

AU - Germer, Christoph-Thomas

AU - Fassnacht, Martin

AU - Jurowich, Christian

PY - 2019/2/15

Y1 - 2019/2/15

N2 - Background: In the surgical treatment of adrenocortical carcinoma (ACC), lymphadenectomy may improve oncologic outcome. However, patterns of metastatic lymphatic spread in ACC are unknown.Methods: Clinical data of patients included in the European Network for the Study of Adrenal Tumors (ENSAT) registry were retrospectively reviewed. Inclusion criteria were: nonmetastatic ACC, complete resection of the primary tumor, a disease-free time of > 3 months, and lymph node metastases as the first disease relapse. The retroperitoneal lymphatic drainage area was evaluated by using follow-up imaging.Results: Of 971 patients from the ENSAT registry, 56 patients were included. In left-sided ACC (n = 36), lymphatic recurrence was detected in the left renal hilum (50%), in the perirenal fat tissue cranial to the renal hilum (ventral, 47%; dorsal, 55%), para-aortic (47%), interaorto-caval (22%), and/or in the perirenal fat tissue caudal to the renal hilum (ventral, 20%; dorsal, 17%). In right-sided ACC (n = 20), lymph node metastases were detected in the perirenal fat tissue cranial to the renal hilum (dorsal, 55%; ventral, 45%), interaorto-caval (35%), in the area of the right renal artery (10%), and/or paracaval (15%). Patients with right-sided ACC showed left-paraaortic lymph node recurrences in 10% of cases.Conclusion: Metastatic lymphatic spread appears to be more extensive than previously thought. The distribution pattern of lymph node metastases described in our study could be used as a guide for a more extended lymph node dissection.

AB - Background: In the surgical treatment of adrenocortical carcinoma (ACC), lymphadenectomy may improve oncologic outcome. However, patterns of metastatic lymphatic spread in ACC are unknown.Methods: Clinical data of patients included in the European Network for the Study of Adrenal Tumors (ENSAT) registry were retrospectively reviewed. Inclusion criteria were: nonmetastatic ACC, complete resection of the primary tumor, a disease-free time of > 3 months, and lymph node metastases as the first disease relapse. The retroperitoneal lymphatic drainage area was evaluated by using follow-up imaging.Results: Of 971 patients from the ENSAT registry, 56 patients were included. In left-sided ACC (n = 36), lymphatic recurrence was detected in the left renal hilum (50%), in the perirenal fat tissue cranial to the renal hilum (ventral, 47%; dorsal, 55%), para-aortic (47%), interaorto-caval (22%), and/or in the perirenal fat tissue caudal to the renal hilum (ventral, 20%; dorsal, 17%). In right-sided ACC (n = 20), lymph node metastases were detected in the perirenal fat tissue cranial to the renal hilum (dorsal, 55%; ventral, 45%), interaorto-caval (35%), in the area of the right renal artery (10%), and/or paracaval (15%). Patients with right-sided ACC showed left-paraaortic lymph node recurrences in 10% of cases.Conclusion: Metastatic lymphatic spread appears to be more extensive than previously thought. The distribution pattern of lymph node metastases described in our study could be used as a guide for a more extended lymph node dissection.

UR - http://www.scopus.com/inward/record.url?scp=85056668281&partnerID=8YFLogxK

U2 - 10.1245/s10434-018-6999-z

DO - 10.1245/s10434-018-6999-z

M3 - Article

VL - 26

SP - 531

EP - 538

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 2

ER -