Patient and public perspectives on cell and gene therapies: a systematic review

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Patient and public perspectives on cell and gene therapies : a systematic review. / Aiyegbusi, Olalekan Lee; Macpherson, Karen ; Elston, Lauren ; Myles, Susan ; Washington, Jennifer ; Sungum , Nisha ; Briggs, Mark ; Newsome, Philip; Calvert, Melanie.

In: Nature Communications, Vol. 11, No. 1, 6265, 08.12.2020.

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Aiyegbusi, Olalekan Lee ; Macpherson, Karen ; Elston, Lauren ; Myles, Susan ; Washington, Jennifer ; Sungum , Nisha ; Briggs, Mark ; Newsome, Philip ; Calvert, Melanie. / Patient and public perspectives on cell and gene therapies : a systematic review. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Bibtex

@article{6feb57eb836146a9a4f5c46d64eb6ce6,
title = "Patient and public perspectives on cell and gene therapies: a systematic review",
abstract = "Cell and gene therapies offer opportunities for treating disease with potential to restore function, and cure disease. However, they are not without risk and pose complex logistical, economic, ethical and social challenges for health systems. Here we report our systematic review of the current evidence on patient and public knowledge and perspectives of cell and gene therapies, to inform future research, education and awareness raising activities. We screened 10,735 titles and abstracts, and evaluated the full texts of 151 publications. The final selection was 35 publications. Four themes were generated from the narrative synthesis of the study findings namely: 1) Knowledge and understanding of cell and gene therapies, 2) Acceptance of cell and gene therapies 3) Understanding of risk and benefits of therapy, and 4) Information needs and current sources of information. As potential funders or future recipients, it is important that the public and patients are aware of these therapies, understand the issues involved, and can contribute to the debate. This review highlights the need for appropriate patient and public education on the various aspects of cell and gene therapies. High quality studies exploring patient and public opinions and experiences of cell and gene therapy are required. Patient and public perceptions of these therapies, alongside evidence of clinical and cost-effectiveness, will be central to their uptake and use. ",
author = "Aiyegbusi, {Olalekan Lee} and Karen Macpherson and Lauren Elston and Susan Myles and Jennifer Washington and Nisha Sungum and Mark Briggs and Philip Newsome and Melanie Calvert",
year = "2020",
month = dec,
day = "8",
doi = "10.1038/s41467-020-20096-1",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Patient and public perspectives on cell and gene therapies

T2 - a systematic review

AU - Aiyegbusi, Olalekan Lee

AU - Macpherson, Karen

AU - Elston, Lauren

AU - Myles, Susan

AU - Washington, Jennifer

AU - Sungum , Nisha

AU - Briggs, Mark

AU - Newsome, Philip

AU - Calvert, Melanie

PY - 2020/12/8

Y1 - 2020/12/8

N2 - Cell and gene therapies offer opportunities for treating disease with potential to restore function, and cure disease. However, they are not without risk and pose complex logistical, economic, ethical and social challenges for health systems. Here we report our systematic review of the current evidence on patient and public knowledge and perspectives of cell and gene therapies, to inform future research, education and awareness raising activities. We screened 10,735 titles and abstracts, and evaluated the full texts of 151 publications. The final selection was 35 publications. Four themes were generated from the narrative synthesis of the study findings namely: 1) Knowledge and understanding of cell and gene therapies, 2) Acceptance of cell and gene therapies 3) Understanding of risk and benefits of therapy, and 4) Information needs and current sources of information. As potential funders or future recipients, it is important that the public and patients are aware of these therapies, understand the issues involved, and can contribute to the debate. This review highlights the need for appropriate patient and public education on the various aspects of cell and gene therapies. High quality studies exploring patient and public opinions and experiences of cell and gene therapy are required. Patient and public perceptions of these therapies, alongside evidence of clinical and cost-effectiveness, will be central to their uptake and use.

AB - Cell and gene therapies offer opportunities for treating disease with potential to restore function, and cure disease. However, they are not without risk and pose complex logistical, economic, ethical and social challenges for health systems. Here we report our systematic review of the current evidence on patient and public knowledge and perspectives of cell and gene therapies, to inform future research, education and awareness raising activities. We screened 10,735 titles and abstracts, and evaluated the full texts of 151 publications. The final selection was 35 publications. Four themes were generated from the narrative synthesis of the study findings namely: 1) Knowledge and understanding of cell and gene therapies, 2) Acceptance of cell and gene therapies 3) Understanding of risk and benefits of therapy, and 4) Information needs and current sources of information. As potential funders or future recipients, it is important that the public and patients are aware of these therapies, understand the issues involved, and can contribute to the debate. This review highlights the need for appropriate patient and public education on the various aspects of cell and gene therapies. High quality studies exploring patient and public opinions and experiences of cell and gene therapy are required. Patient and public perceptions of these therapies, alongside evidence of clinical and cost-effectiveness, will be central to their uptake and use.

U2 - 10.1038/s41467-020-20096-1

DO - 10.1038/s41467-020-20096-1

M3 - Article

C2 - 33293538

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 6265

ER -