Partial leptin deficiency and human adiposity

Research output: Contribution to journalArticle


  • IS Farooqi
  • JM Keogh
  • Sridhar Kamath
  • S Jones
  • WT Gibson
  • R Trussell
  • SA Jebb
  • S O'Rahilly

Colleges, School and Institutes


The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).


Original languageEnglish
Pages (from-to)34-35
Number of pages2
Issue number6859
Publication statusPublished - 1 Nov 2001

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