Partial leptin deficiency and human adiposity

IS Farooqi; JM Keogh; Sridhar Kamath; S Jones; WT Gibson; R Trussell; SA Jebb; Gregory Lip; S O'Rahilly

doi:10.1038/35102112

Partial leptin deficiency and human adiposity

IS Farooqi, JM Keogh, Sridhar Kamath, S Jones, WT Gibson, R Trussell, SA Jebb, Gregory Lip, S O'Rahilly

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Abstract

The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).

Original language	English
Pages (from-to)	34-35
Number of pages	2
Journal	Nature
Volume	414
Issue number	6859
DOIs	https://doi.org/10.1038/35102112
Publication status	Published - 1 Nov 2001

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AU - Keogh, JM

AU - Kamath, Sridhar

AU - Jones, S

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AU - Trussell, R

AU - Jebb, SA

AU - Lip, Gregory

AU - O'Rahilly, S

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AB - The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).

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Partial leptin deficiency and human adiposity

Abstract

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