Parameters for reliable results in genetic association studies

I Dahlman, IA Eaves, R Kosoy, VA Morrison, Joanne King, Stephen Gough, Amit Allahabadia, Jayne Franklyn, J Tuomilheto, E Tuomelito-Wolf, F Cucca, C Guja, C Ionescu-Tirgoviste, H Stevens, P Carr, S Nutland, P McKinney, JP Shield, W Wang, HJ CordellN Walker, JA Todd, P Concannon

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.
Original languageEnglish
Pages (from-to)149-150
Number of pages2
JournalNature Genetics
Volume30
Issue number2
DOIs
Publication statusPublished - 1 Feb 2002

Fingerprint

Dive into the research topics of 'Parameters for reliable results in genetic association studies'. Together they form a unique fingerprint.

Cite this