Parallel independent evolution of pathogenicity within the genus Yersinia

Research output: Contribution to journalArticle

Authors

  • Sandra Reuter
  • Thomas R Connor
  • Lars Barquist
  • Danielle Walker
  • Theresa Feltwell
  • Simon R Harris
  • Maria Fookes
  • Miquette E Hall
  • Nicola K Petty
  • Thilo M Fuchs
  • Jukka Corander
  • Muriel Dufour
  • Tamara Ringwood
  • Cyril Savin
  • Christiane Bouchier
  • Liliane Martin
  • Minna Miettinen
  • Mikhail Shubin
  • Julia M Riehm
  • Riikka Laukkanen-Ninios
  • Leila M Sihvonen
  • Anja Siitonen
  • Mikael Skurnik
  • Juliana Pfrimer Falcão
  • Hiroshi Fukushima
  • Holger C Scholz
  • Michael B Prentice
  • Brendan W Wren
  • Elisabeth Carniel
  • Mark Achtman
  • Nicholas R Thomson

Colleges, School and Institutes

Abstract

The genus Yersinia has been used as a model system to study pathogen evolution. Using whole-genome sequencing of all Yersinia species, we delineate the gene complement of the whole genus and define patterns of virulence evolution. Multiple distinct ecological specializations appear to have split pathogenic strains from environmental, nonpathogenic lineages. This split demonstrates that contrary to hypotheses that all pathogenic Yersinia species share a recent common pathogenic ancestor, they have evolved independently but followed parallel evolutionary paths in acquiring the same virulence determinants as well as becoming progressively more limited metabolically. Shared virulence determinants are limited to the virulence plasmid pYV and the attachment invasion locus ail. These acquisitions, together with genomic variations in metabolic pathways, have resulted in the parallel emergence of related pathogens displaying an increasingly specialized lifestyle with a spectrum of virulence potential, an emerging theme in the evolution of other important human pathogens.

Details

Original languageEnglish
Pages (from-to)6768-73
Number of pages6
JournalNational Academy of Sciences. Proceedings
Volume111
Issue number18
Publication statusPublished - 6 May 2014

Keywords

  • Evolution, Molecular, Genome, Bacterial, Humans, Metabolic Networks and Pathways, Phylogeny, Species Specificity, Virulence, Yersinia, Yersinia enterocolitica