TY - JOUR
T1 - Paradoxical facilitation after depotentiation protocol can precede dyskinesia onset in early Parkinson’s disease
AU - Lago-Rodriguez, Angel
AU - Ponzo, Viviana
AU - Jenkinson, Ned
AU - Benitez-Rivero, Sonia
AU - Del-Olmo, Miguel Fernandez
AU - Hu, Michele
AU - Koch, Giacomo
AU - Cheeran, Binith
PY - 2016/8/26
Y1 - 2016/8/26
N2 - Loss of dopamine, a key modulator of synaptic signalling, and subsequent pulsatile non-physiological levodopa replacement is believed to underlie altered neuroplasticity in Parkinson’s disease (PD). Animal models suggest that maladaptive plasticity (e.g. deficient depotentiation at corticostriatal synapses) is key in the development of levodopa-induced dyskinesia (LID), a common complication following levodopa replacement in PD. Human studies using transcranial magnetic stimulation protocols have shown similar depotentiation deficit in patients with LID. We hypothesized that subtle depotentiation deficits should precede LID if these deficits are mechanistically linked to LID onset. Moreover, patients on pulsatile levodopa-based therapy may show these changes earlier than those treated with levodopa-sparing strategies. We recruited 22 early non-dyskinetic PD patients (
AB - Loss of dopamine, a key modulator of synaptic signalling, and subsequent pulsatile non-physiological levodopa replacement is believed to underlie altered neuroplasticity in Parkinson’s disease (PD). Animal models suggest that maladaptive plasticity (e.g. deficient depotentiation at corticostriatal synapses) is key in the development of levodopa-induced dyskinesia (LID), a common complication following levodopa replacement in PD. Human studies using transcranial magnetic stimulation protocols have shown similar depotentiation deficit in patients with LID. We hypothesized that subtle depotentiation deficits should precede LID if these deficits are mechanistically linked to LID onset. Moreover, patients on pulsatile levodopa-based therapy may show these changes earlier than those treated with levodopa-sparing strategies. We recruited 22 early non-dyskinetic PD patients (
KW - Depotentiation
KW - Levodopa-induced dyskinesia
KW - Parkinson’s disease
KW - Potentiation
KW - Synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=84983775774&partnerID=8YFLogxK
U2 - 10.1007/s00221-016-4759-5
DO - 10.1007/s00221-016-4759-5
M3 - Article
AN - SCOPUS:84983775774
SN - 0014-4819
SP - 1
EP - 9
JO - Experimental Brain Research
JF - Experimental Brain Research
ER -