Panniculitis secondary to extravasation of clarithromycin in a patient with alpha-1-antitrypsin deficiency (phenotype PiZ)

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alpha 1-Antitrypsin deficiency (AATD) is known to be associated with panniculitis. Although reports of this association are rare, the true incidence may be unappreciated because of underdiagnosis of AATD. We report a case of panniculitis occurring in a 34-year-old woman with severe AATD following the extravasation of clarithromycin infused intravenously for treatment of community-acquired pneumonia. Resolution occurred with conservative management. The histopathology and management of this unusual condition are discussed, with a review of the literature.


Original languageEnglish
Pages (from-to)410-413
Number of pages4
JournalBritish Journal of Dermatology
Issue number2
Publication statusPublished - 1 Aug 2003