Palladium-polymer nanoreactors for the aqueous asymmetric synthesis of therapeutic flavonoids

E. Lestini; L.D. Blackman; C.M. Zammit; T. Chen; R.J. Williams; M. Inam; B. Couturaud; R.K. O'Reilly

doi:10.1039/c7py02050c

Palladium-polymer nanoreactors for the aqueous asymmetric synthesis of therapeutic flavonoids

E. Lestini, L.D. Blackman, C.M. Zammit, T. Chen, R.J. Williams, M. Inam, B. Couturaud, R.K. O'Reilly

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Polymeric core–shell micelles incorporating a chiral palladium pyridinooxazoline catalyst are presented as nanoreactors for the aqueous asymmetric synthesis of flavanones, a class of flavonoids with therapeutic properties. Use of the nanoreactor was found to increase catalyst activity, enabling catalysis at room temperature, with low palladium loadings and without any additives.

Original language	English
Journal	Polymer Chemistry
Issue number	7
Early online date	30 Jan 2018
DOIs	https://doi.org/10.1039/c7py02050c
Publication status	Published - 21 Feb 2018

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title = "Palladium-polymer nanoreactors for the aqueous asymmetric synthesis of therapeutic flavonoids",

abstract = "Polymeric core–shell micelles incorporating a chiral palladium pyridinooxazoline catalyst are presented as nanoreactors for the aqueous asymmetric synthesis of flavanones, a class of flavonoids with therapeutic properties. Use of the nanoreactor was found to increase catalyst activity, enabling catalysis at room temperature, with low palladium loadings and without any additives.",

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T1 - Palladium-polymer nanoreactors for the aqueous asymmetric synthesis of therapeutic flavonoids

AU - Lestini, E.

AU - Blackman, L.D.

AU - Zammit, C.M.

AU - Chen, T.

AU - Williams, R.J.

AU - Inam, M.

AU - Couturaud, B.

AU - O'Reilly, R.K.

PY - 2018/2/21

Y1 - 2018/2/21

N2 - Polymeric core–shell micelles incorporating a chiral palladium pyridinooxazoline catalyst are presented as nanoreactors for the aqueous asymmetric synthesis of flavanones, a class of flavonoids with therapeutic properties. Use of the nanoreactor was found to increase catalyst activity, enabling catalysis at room temperature, with low palladium loadings and without any additives.

AB - Polymeric core–shell micelles incorporating a chiral palladium pyridinooxazoline catalyst are presented as nanoreactors for the aqueous asymmetric synthesis of flavanones, a class of flavonoids with therapeutic properties. Use of the nanoreactor was found to increase catalyst activity, enabling catalysis at room temperature, with low palladium loadings and without any additives.

U2 - 10.1039/c7py02050c

DO - 10.1039/c7py02050c

M3 - Article

SN - 1759-9954

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 7

ER -

Palladium-polymer nanoreactors for the aqueous asymmetric synthesis of therapeutic flavonoids

Abstract

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