Palladium-polymer nanoreactors for the aqueous asymmetric synthesis of therapeutic flavonoids

Research output: Contribution to journalArticlepeer-review

Authors

  • E. Lestini
  • L.D. Blackman
  • T. Chen
  • R.J. Williams
  • M. Inam

Colleges, School and Institutes

Abstract

Polymeric core–shell micelles incorporating a chiral palladium pyridinooxazoline catalyst are presented as nanoreactors for the aqueous asymmetric synthesis of flavanones, a class of flavonoids with therapeutic properties. Use of the nanoreactor was found to increase catalyst activity, enabling catalysis at room temperature, with low palladium loadings and without any additives.

Details

Original languageEnglish
JournalPolymer Chemistry
Issue number7
Early online date30 Jan 2018
Publication statusPublished - 21 Feb 2018