Palladium (II) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors

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New palladium complexes with thiosemicarbazonate ligands derived from pyrene exhibit potent antiproliferative activity against A2780 and cisplatin-resistant A2780Cis human ovarian cancer cells, which is dependent on substituent groups of the thiosemicarbazone ligands. Cellular accumulation and distribution studies confirmed that palladium enters the cell nucleus. DNA and topoisomerase IB studies show that one complex is a potent TopIB inhibitor, with selectivity for cancer versus normal cells.


Original languageEnglish
Pages (from-to)16509-16517
Number of pages9
JournalDalton Transactions
Issue number44
Early online date30 Oct 2019
Publication statusE-pub ahead of print - 30 Oct 2019