OX40-ligand and CD30-ligand are expressed on adult but not neonatal CD4 +CD3-inducer cells: evidence that IL7 signals regulate CD30-ligand but not OX40-ligand expression

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@article{81fe35423bb44741a275cc0d507fd6b0,
title = "OX40-ligand and CD30-ligand are expressed on adult but not neonatal CD4 +CD3-inducer cells: evidence that IL7 signals regulate CD30-ligand but not OX40-ligand expression",
abstract = "In this report, we have examined the expression of the T cell survival signals, OX40 ligand (OX40L) and CD30 ligand (CD30L) on CD4(+)CD3(-)CD11c(-)B220(-)IL-7Ralpha(+) inducer cells from birth to adulthood in mice. We found that adult but not neonatal inducer cells expressed high levels of OX40L and CD30L, whereas their expression of TNF-related activation-induced cytokine (TRANCE) and receptor activator of NF-kappaB (RANK) was comparable. The failure of neonatal inducer cells to express the ligands that rescue T cells helps to explain why exposure to Ag in neonatal life induces tolerance rather than immunity. The expression of OX40L and CD30L on inducer cells increased gradually in the first few weeks of life achieving essentially normal levels around the time mice were weaned. We found that IL-7 signaling through the common cytokine receptor gamma-chain was critical for the optimal expression of both TNF-related activation-induced cytokine and CD30L but not OX40L. Furthermore, glucocorticoids, which potently suppress T effector function, did not influence the expression of OX40L and CD30L in the presence of IL-7.",
author = "Mi-Yeon Kim and Graham Anderson and Andrea White and Eric Jenkinson and Wiebke Arlt and IL Martensson and L Erlandsson and Peter Lane",
year = "2005",
month = jan,
day = "1",
language = "English",
volume = "174",
pages = "6686--91",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",

}

RIS

TY - JOUR

T1 - OX40-ligand and CD30-ligand are expressed on adult but not neonatal CD4 +CD3-inducer cells: evidence that IL7 signals regulate CD30-ligand but not OX40-ligand expression

AU - Kim, Mi-Yeon

AU - Anderson, Graham

AU - White, Andrea

AU - Jenkinson, Eric

AU - Arlt, Wiebke

AU - Martensson, IL

AU - Erlandsson, L

AU - Lane, Peter

PY - 2005/1/1

Y1 - 2005/1/1

N2 - In this report, we have examined the expression of the T cell survival signals, OX40 ligand (OX40L) and CD30 ligand (CD30L) on CD4(+)CD3(-)CD11c(-)B220(-)IL-7Ralpha(+) inducer cells from birth to adulthood in mice. We found that adult but not neonatal inducer cells expressed high levels of OX40L and CD30L, whereas their expression of TNF-related activation-induced cytokine (TRANCE) and receptor activator of NF-kappaB (RANK) was comparable. The failure of neonatal inducer cells to express the ligands that rescue T cells helps to explain why exposure to Ag in neonatal life induces tolerance rather than immunity. The expression of OX40L and CD30L on inducer cells increased gradually in the first few weeks of life achieving essentially normal levels around the time mice were weaned. We found that IL-7 signaling through the common cytokine receptor gamma-chain was critical for the optimal expression of both TNF-related activation-induced cytokine and CD30L but not OX40L. Furthermore, glucocorticoids, which potently suppress T effector function, did not influence the expression of OX40L and CD30L in the presence of IL-7.

AB - In this report, we have examined the expression of the T cell survival signals, OX40 ligand (OX40L) and CD30 ligand (CD30L) on CD4(+)CD3(-)CD11c(-)B220(-)IL-7Ralpha(+) inducer cells from birth to adulthood in mice. We found that adult but not neonatal inducer cells expressed high levels of OX40L and CD30L, whereas their expression of TNF-related activation-induced cytokine (TRANCE) and receptor activator of NF-kappaB (RANK) was comparable. The failure of neonatal inducer cells to express the ligands that rescue T cells helps to explain why exposure to Ag in neonatal life induces tolerance rather than immunity. The expression of OX40L and CD30L on inducer cells increased gradually in the first few weeks of life achieving essentially normal levels around the time mice were weaned. We found that IL-7 signaling through the common cytokine receptor gamma-chain was critical for the optimal expression of both TNF-related activation-induced cytokine and CD30L but not OX40L. Furthermore, glucocorticoids, which potently suppress T effector function, did not influence the expression of OX40L and CD30L in the presence of IL-7.

M3 - Article

C2 - 15905508

VL - 174

SP - 6686

EP - 6691

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

ER -