Organ-specific mechanisms linking innate and adaptive antifungal immunity
Research output: Contribution to journal › Article
Colleges, School and Institutes
- National Institute of Allergy and Infectious Diseases
Fungal infections remain a significant global health problem in humans. Fungi infect millions of people worldwide and cause from acute superficial infections to life-threatening systemic disease to chronic illnesses. Trying to decipher the complex innate and adaptive immune mechanisms that protect humans from pathogenic fungi is therefore a key research goal that may lead to immune-based therapeutic strategies and improved patient outcomes. In this review, we summarize how the cells and molecules of the innate immune system activate the adaptive immune system to elicit long-term immunity to fungi. We present current knowledge and exciting new advances in the context of organ-specific immunity, outlining the tissue-specific tropisms for the major pathogenic fungi of humans, the antifungal functions of tissue-resident myeloid cells, and the adaptive immune responses required to protect specific organs from fungal challenge.
|Journal||Seminars in Cell and Developmental Biology|
|Early online date||1 Feb 2018|
|Publication status||E-pub ahead of print - 1 Feb 2018|