Organ-specific mechanisms linking innate and adaptive antifungal immunity

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • National Institute of Allergy and Infectious Diseases

Abstract

Fungal infections remain a significant global health problem in humans. Fungi infect millions of people worldwide and cause from acute superficial infections to life-threatening systemic disease to chronic illnesses. Trying to decipher the complex innate and adaptive immune mechanisms that protect humans from pathogenic fungi is therefore a key research goal that may lead to immune-based therapeutic strategies and improved patient outcomes. In this review, we summarize how the cells and molecules of the innate immune system activate the adaptive immune system to elicit long-term immunity to fungi. We present current knowledge and exciting new advances in the context of organ-specific immunity, outlining the tissue-specific tropisms for the major pathogenic fungi of humans, the antifungal functions of tissue-resident myeloid cells, and the adaptive immune responses required to protect specific organs from fungal challenge.

Details

Original languageEnglish
JournalSeminars in Cell and Developmental Biology
Early online date1 Feb 2018
Publication statusE-pub ahead of print - 1 Feb 2018

Keywords

  • Alveolar macrophage, Card9, Fungi, Kupffer, Langerhans, Microglia

ASJC Scopus subject areas