Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies

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Organometallic nucleoside analogues with ferrocenyl linker groups : synthesis and cancer cell line studies. / Nguyen, Huy V; Sallustrau, Antoine; Balzarini, Jan; Bedford, Matthew R; Eden, John C; Georgousi, Niki; Hodges, Nikolas J; Kedge, Jonathan; Mehellou, Youcef; Tselepis, Chris; Tucker, James H R.

In: Journal of Medicinal Chemistry, Vol. 57, No. 13, 10.07.2014, p. 5817-22.

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@article{bb982fb6cbbb4c279a6f1aca9ddd4c47,
title = "Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies",
abstract = "Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.",
keywords = "Animals, Antineoplastic Agents, Cell Line, Tumor, Ferrous Compounds, Humans, Leukemia L1210, Nucleosides, Organometallic Compounds",
author = "Nguyen, {Huy V} and Antoine Sallustrau and Jan Balzarini and Bedford, {Matthew R} and Eden, {John C} and Niki Georgousi and Hodges, {Nikolas J} and Jonathan Kedge and Youcef Mehellou and Chris Tselepis and Tucker, {James H R}",
year = "2014",
month = jul,
day = "10",
doi = "10.1021/jm500246h",
language = "English",
volume = "57",
pages = "5817--22",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "13",

}

RIS

TY - JOUR

T1 - Organometallic nucleoside analogues with ferrocenyl linker groups

T2 - synthesis and cancer cell line studies

AU - Nguyen, Huy V

AU - Sallustrau, Antoine

AU - Balzarini, Jan

AU - Bedford, Matthew R

AU - Eden, John C

AU - Georgousi, Niki

AU - Hodges, Nikolas J

AU - Kedge, Jonathan

AU - Mehellou, Youcef

AU - Tselepis, Chris

AU - Tucker, James H R

PY - 2014/7/10

Y1 - 2014/7/10

N2 - Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.

AB - Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.

KW - Animals

KW - Antineoplastic Agents

KW - Cell Line, Tumor

KW - Ferrous Compounds

KW - Humans

KW - Leukemia L1210

KW - Nucleosides

KW - Organometallic Compounds

U2 - 10.1021/jm500246h

DO - 10.1021/jm500246h

M3 - Article

C2 - 24905419

VL - 57

SP - 5817

EP - 5822

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 13

ER -