Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies

Research output: Contribution to journalArticle

Authors

  • Huy V Nguyen
  • Antoine Sallustrau
  • Jan Balzarini
  • John C Eden
  • Niki Georgousi
  • Jim Tucker

Abstract

Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.

Details

Original languageEnglish
Pages (from-to)5817-22
Number of pages6
JournalJournal of Medicinal Chemistry
Volume57
Issue number13
Early online date6 Jun 2014
Publication statusPublished - 10 Jul 2014

Keywords

  • Animals, Antineoplastic Agents, Cell Line, Tumor, Ferrous Compounds, Humans, Leukemia L1210, Nucleosides, Organometallic Compounds