Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies
Research output: Contribution to journal › Article › peer-review
Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.
|Number of pages||6|
|Journal||Journal of Medicinal Chemistry|
|Early online date||6 Jun 2014|
|Publication status||Published - 10 Jul 2014|
- Animals, Antineoplastic Agents, Cell Line, Tumor, Ferrous Compounds, Humans, Leukemia L1210, Nucleosides, Organometallic Compounds