Organometallic nucleoside analogues: effect of the metallocene metal atom on cancer cell line toxicity

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Organometallic nucleoside analogues : effect of the metallocene metal atom on cancer cell line toxicity. / Ismail, Media K; Armstrong, Katie A; Hodder, Samantha L; Horswell, Sarah L; Male, Louise; Nguyen, Huy V; Wilkinson, Edward A; Hodges, Nikolas J; Tucker, James H R.

In: Dalton Transactions, Vol. 49, No. 4, 28.01.2020, p. 1181-1190.

Research output: Contribution to journalArticlepeer-review

Harvard

Ismail, MK, Armstrong, KA, Hodder, SL, Horswell, SL, Male, L, Nguyen, HV, Wilkinson, EA, Hodges, NJ & Tucker, JHR 2020, 'Organometallic nucleoside analogues: effect of the metallocene metal atom on cancer cell line toxicity', Dalton Transactions, vol. 49, no. 4, pp. 1181-1190. https://doi.org/10.1039/c9dt04174e

APA

Ismail, M. K., Armstrong, K. A., Hodder, S. L., Horswell, S. L., Male, L., Nguyen, H. V., Wilkinson, E. A., Hodges, N. J., & Tucker, J. H. R. (2020). Organometallic nucleoside analogues: effect of the metallocene metal atom on cancer cell line toxicity. Dalton Transactions, 49(4), 1181-1190. https://doi.org/10.1039/c9dt04174e

Vancouver

Ismail MK, Armstrong KA, Hodder SL, Horswell SL, Male L, Nguyen HV et al. Organometallic nucleoside analogues: effect of the metallocene metal atom on cancer cell line toxicity. Dalton Transactions. 2020 Jan 28;49(4):1181-1190. https://doi.org/10.1039/c9dt04174e

Author

Ismail, Media K ; Armstrong, Katie A ; Hodder, Samantha L ; Horswell, Sarah L ; Male, Louise ; Nguyen, Huy V ; Wilkinson, Edward A ; Hodges, Nikolas J ; Tucker, James H R. / Organometallic nucleoside analogues : effect of the metallocene metal atom on cancer cell line toxicity. In: Dalton Transactions. 2020 ; Vol. 49, No. 4. pp. 1181-1190.

Bibtex

@article{765b18ea6c7c40cd9d6b9e2abd49fbcd,
title = "Organometallic nucleoside analogues: effect of the metallocene metal atom on cancer cell line toxicity",
abstract = "A new chiral organometallic nucleoside analogue containing ruthenocene is reported, in which alkylthymine and alkylhydroxyl groups are attached in adjacent positions on one cyclopentadienyl ring. The synthetic procedures for this metallocene derivative and two control compounds are described, along with their characterisation by cyclic voltammetry and X-ray crystallography. Their biological activities in a human pancreatic cancer cell line (MIA-Pa-Ca-2) were significantly lower than those of three previously reported analogous ferrocene compounds, indicating that the choice of metallocene metal atom (Fe or Ru) plays a pivotal role in determining the anticancer properties of these nucleoside analogues, which in turn suggests a different mode of action from that of a conventional nucleoside analogue.",
author = "Ismail, {Media K} and Armstrong, {Katie A} and Hodder, {Samantha L} and Horswell, {Sarah L} and Louise Male and Nguyen, {Huy V} and Wilkinson, {Edward A} and Hodges, {Nikolas J} and Tucker, {James H R}",
year = "2020",
month = jan,
day = "28",
doi = "10.1039/c9dt04174e",
language = "English",
volume = "49",
pages = "1181--1190",
journal = "Dalton Transactions",
issn = "1477-9234",
publisher = "Royal Society of Chemistry",
number = "4",

}

RIS

TY - JOUR

T1 - Organometallic nucleoside analogues

T2 - effect of the metallocene metal atom on cancer cell line toxicity

AU - Ismail, Media K

AU - Armstrong, Katie A

AU - Hodder, Samantha L

AU - Horswell, Sarah L

AU - Male, Louise

AU - Nguyen, Huy V

AU - Wilkinson, Edward A

AU - Hodges, Nikolas J

AU - Tucker, James H R

PY - 2020/1/28

Y1 - 2020/1/28

N2 - A new chiral organometallic nucleoside analogue containing ruthenocene is reported, in which alkylthymine and alkylhydroxyl groups are attached in adjacent positions on one cyclopentadienyl ring. The synthetic procedures for this metallocene derivative and two control compounds are described, along with their characterisation by cyclic voltammetry and X-ray crystallography. Their biological activities in a human pancreatic cancer cell line (MIA-Pa-Ca-2) were significantly lower than those of three previously reported analogous ferrocene compounds, indicating that the choice of metallocene metal atom (Fe or Ru) plays a pivotal role in determining the anticancer properties of these nucleoside analogues, which in turn suggests a different mode of action from that of a conventional nucleoside analogue.

AB - A new chiral organometallic nucleoside analogue containing ruthenocene is reported, in which alkylthymine and alkylhydroxyl groups are attached in adjacent positions on one cyclopentadienyl ring. The synthetic procedures for this metallocene derivative and two control compounds are described, along with their characterisation by cyclic voltammetry and X-ray crystallography. Their biological activities in a human pancreatic cancer cell line (MIA-Pa-Ca-2) were significantly lower than those of three previously reported analogous ferrocene compounds, indicating that the choice of metallocene metal atom (Fe or Ru) plays a pivotal role in determining the anticancer properties of these nucleoside analogues, which in turn suggests a different mode of action from that of a conventional nucleoside analogue.

U2 - 10.1039/c9dt04174e

DO - 10.1039/c9dt04174e

M3 - Article

C2 - 31897458

VL - 49

SP - 1181

EP - 1190

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9234

IS - 4

ER -