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Abstract
A new chiral organometallic nucleoside analogue containing ruthenocene is reported, in which alkylthymine and alkylhydroxyl groups are attached in adjacent positions on one cyclopentadienyl ring. The synthetic procedures for this metallocene derivative and two control compounds are described, along with their characterisation by cyclic voltammetry and X-ray crystallography. Their biological activities in a human pancreatic cancer cell line (MIA-Pa-Ca-2) were significantly lower than those of three previously reported analogous ferrocene compounds, indicating that the choice of metallocene metal atom (Fe or Ru) plays a pivotal role in determining the anticancer properties of these nucleoside analogues, which in turn suggests a different mode of action from that of a conventional nucleoside analogue.
Original language | English |
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Pages (from-to) | 1181-1190 |
Number of pages | 10 |
Journal | Dalton Transactions |
Volume | 49 |
Issue number | 4 |
Early online date | 16 Dec 2019 |
DOIs | |
Publication status | Published - 28 Jan 2020 |
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Dive into the research topics of 'Organometallic nucleoside analogues: effect of the metallocene metal atom on cancer cell line toxicity'. Together they form a unique fingerprint.Projects
- 1 Finished
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Functional DNA-based assemblies
Engineering & Physical Science Research Council
16/03/09 → 31/03/14
Project: Research Councils