Organocatalytic Stereoconvergent Synthesis of α-CF 3 Amides: Triketopiperazines and Their Heterocyclic Metamorphosis
Research output: Contribution to journal › Article › peer-review
Colleges, School and Institutes
- University of Birmingham
The highly enantioselective alkylation of α-CF3 enolates, generated from triketopiperazines, has been accomplished through use of a bifunctional thiourea organocatalyst to facilitate 1,4-addition to varied enone acceptors. On treatment with appropriate nitrogen nucleophiles, the chiral triketopiperazine products undergo a metamorphosis, to provide novel fused heterocyclic lactams such as extended pyrazolopyrimidines.
|Journal||Chemistry: A European Journal|
|Early online date||12 Jun 2017|
|Publication status||E-pub ahead of print - 12 Jun 2017|