Oral cefuroxime axetil: clinical pharmacology and comparative dose studies in urinary tract infection

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Oral cefuroxime axetil : clinical pharmacology and comparative dose studies in urinary tract infection. / Adams, D H; Wood, M J; Farrell, I D; Fox, C; Ball, A P.

In: Journal of Antimicrobial Chemotherapy, Vol. 16, No. 3, 09.1985, p. 359-66.

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@article{05da3b4e19e940fbbab4df96bbf6463c,
title = "Oral cefuroxime axetil: clinical pharmacology and comparative dose studies in urinary tract infection",
abstract = "Cefuroxime axetil, an orally absorbed pro-drug of cefuroxime was used to treat a mainly elderly group of patients with symptomatic urinary tract infections. The drug was clinically effective and the bacteriological short term and long term cure rates (55% and 48% respectively) comparable to those of other antibiotics. The study had to be terminated however after the development of three cases of antibiotic associated colitis. Studies of the pharmacokinetics of the drug in volunteers gave inconsistent results suggesting that there may be variable bioavailability of the compound.",
keywords = "Administration, Oral, Adolescent, Adult, Aged, Bacteria, Biological Availability, Cefuroxime, Cephalosporins, Humans, Kinetics, Microbial Sensitivity Tests, Middle Aged, Urinary Tract Infections",
author = "Adams, {D H} and Wood, {M J} and Farrell, {I D} and C Fox and Ball, {A P}",
year = "1985",
month = sep,
language = "English",
volume = "16",
pages = "359--66",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Oral cefuroxime axetil

T2 - clinical pharmacology and comparative dose studies in urinary tract infection

AU - Adams, D H

AU - Wood, M J

AU - Farrell, I D

AU - Fox, C

AU - Ball, A P

PY - 1985/9

Y1 - 1985/9

N2 - Cefuroxime axetil, an orally absorbed pro-drug of cefuroxime was used to treat a mainly elderly group of patients with symptomatic urinary tract infections. The drug was clinically effective and the bacteriological short term and long term cure rates (55% and 48% respectively) comparable to those of other antibiotics. The study had to be terminated however after the development of three cases of antibiotic associated colitis. Studies of the pharmacokinetics of the drug in volunteers gave inconsistent results suggesting that there may be variable bioavailability of the compound.

AB - Cefuroxime axetil, an orally absorbed pro-drug of cefuroxime was used to treat a mainly elderly group of patients with symptomatic urinary tract infections. The drug was clinically effective and the bacteriological short term and long term cure rates (55% and 48% respectively) comparable to those of other antibiotics. The study had to be terminated however after the development of three cases of antibiotic associated colitis. Studies of the pharmacokinetics of the drug in volunteers gave inconsistent results suggesting that there may be variable bioavailability of the compound.

KW - Administration, Oral

KW - Adolescent

KW - Adult

KW - Aged

KW - Bacteria

KW - Biological Availability

KW - Cefuroxime

KW - Cephalosporins

KW - Humans

KW - Kinetics

KW - Microbial Sensitivity Tests

KW - Middle Aged

KW - Urinary Tract Infections

M3 - Article

C2 - 4055543

VL - 16

SP - 359

EP - 366

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 3

ER -