Abstract
Background
It remains uncertain whether patients with atrial fibrillation (AF) and a single additional stroke risk factor (CHA2DS2-VASc score = 1 in males, 2 in females) should be treated with oral anticoagulation (OAC). We investigated the risk of ischemic stroke, systemic embolism and death in a community-based cohort of unselected AF patients with a 0-1 stroke risk factors, based on the CHA2DS2-VASc score.
Methods
Among 8962 patients with AF seen between 2000 and 2010, 2177 (24%) had 0 or 1 additional stroke risk factor, of which 53% were prescribed OAC.
Results
Over a follow-up of 979±1158 days, 151 (7%) had a major adverse event (stroke/systemic thromboembolism/death). Prescription of OAC was not associated with a better prognosis for stroke/systemic thromboembolism/death for ‘low risk’ patients (ie. CHA2DS2-VASc score = 0 for men or 1 for women) [adjusted Hazard Ratio(HR) 0.68, 95% CI 0.35-1.31, p=0.25 ]. OAC use was independently associated with a better prognosis in AF patients with a single additional stroke risk factor (ie. CHA2DS2-VASc score = 1 in males, 2 in females) [adjusted HR 0.59, 95% CI 0.40-0.86, p=0.007].
Conclusion
Among AF patients with one single additional stroke risk factor (CHA2DS2-VASc score = 1 in males, 2 in females), OAC use was associated with an improved prognosis for stroke/systemic thromboembolism/death.
It remains uncertain whether patients with atrial fibrillation (AF) and a single additional stroke risk factor (CHA2DS2-VASc score = 1 in males, 2 in females) should be treated with oral anticoagulation (OAC). We investigated the risk of ischemic stroke, systemic embolism and death in a community-based cohort of unselected AF patients with a 0-1 stroke risk factors, based on the CHA2DS2-VASc score.
Methods
Among 8962 patients with AF seen between 2000 and 2010, 2177 (24%) had 0 or 1 additional stroke risk factor, of which 53% were prescribed OAC.
Results
Over a follow-up of 979±1158 days, 151 (7%) had a major adverse event (stroke/systemic thromboembolism/death). Prescription of OAC was not associated with a better prognosis for stroke/systemic thromboembolism/death for ‘low risk’ patients (ie. CHA2DS2-VASc score = 0 for men or 1 for women) [adjusted Hazard Ratio(HR) 0.68, 95% CI 0.35-1.31, p=0.25 ]. OAC use was independently associated with a better prognosis in AF patients with a single additional stroke risk factor (ie. CHA2DS2-VASc score = 1 in males, 2 in females) [adjusted HR 0.59, 95% CI 0.40-0.86, p=0.007].
Conclusion
Among AF patients with one single additional stroke risk factor (CHA2DS2-VASc score = 1 in males, 2 in females), OAC use was associated with an improved prognosis for stroke/systemic thromboembolism/death.
| Original language | English |
|---|---|
| Pages (from-to) | 960-968 |
| Journal | Chest |
| Volume | 149 |
| Issue number | 4 |
| Early online date | 12 Jan 2016 |
| DOIs | |
| Publication status | Published - Apr 2016 |