Abstract
Optical mapping is an important tool for assessment of cardiac electrophysiology. We demonstrate a system for quantification and automatic measurement of electrophysiological parameters in isolated cardiac tissue. The system makes use of voltage sensitive fluorescent dyes. These shift in wavelength in response to millivolt changes in potential across cell membranes located on the left atrium. Automated analysis of the pixel-wise measurements yields information on action potential durations and isochronal maps allowing for high throughput of data analysis. The algorithms that we propose reliably describe activation sequences and allow for quantification of conduction velocities.
| Original language | English |
|---|---|
| Pages (from-to) | 368-376 |
| Number of pages | 9 |
| Journal | Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization |
| Volume | 5 |
| Issue number | 5 |
| Early online date | 15 Nov 2015 |
| DOIs | |
| Publication status | E-pub ahead of print - 15 Nov 2015 |
Keywords
- optical mapping
- cardiovascular disease
- voltage imaging
- electrophysiology
- action potential
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Access to Document
- Yu_et_al_Optical_mapping_design_Computer_Methods_Biomechanics_Biomedical_Engineering_Post-Print
This is an Accepted Manuscript of an article published by Taylor & Francis in Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization online on 15/11/2015, available online: http://wwww.tandfonline.com/10.1080/21681163.2015.1081079 Checked December 2015