Optical mapping design for murine atrial electrophysiology

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@article{18804685b7c0452d967d8c6b9e51b50c,
title = "Optical mapping design for murine atrial electrophysiology",
abstract = "Optical mapping is an important tool for assessment of cardiac electrophysiology. We demonstrate a system for quantification and automatic measurement of electrophysiological parameters in isolated cardiac tissue. The system makes use of voltage sensitive fluorescent dyes. These shift in wavelength in response to millivolt changes in potential across cell membranes located on the left atrium. Automated analysis of the pixel-wise measurements yields information on action potential durations and isochronal maps allowing for high throughput of data analysis. The algorithms that we propose reliably describe activation sequences and allow for quantification of conduction velocities.",
keywords = "optical mapping , cardiovascular disease , voltage imaging , electrophysiology , action potential",
author = "T.Y. Yu and H. Dehghani and K. Brain and F. Syeda and Holmes, {A. P.} and P. Kirchhof and L. Fabritz",
year = "2015",
month = nov
day = "15",
doi = "10.1080/21681163.2015.1081079",
language = "English",
volume = "5",
pages = "368--376",
journal = "Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization",
issn = "2168-1163",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - Optical mapping design for murine atrial electrophysiology

AU - Yu, T.Y.

AU - Dehghani, H.

AU - Brain, K.

AU - Syeda, F.

AU - Holmes, A. P.

AU - Kirchhof, P.

AU - Fabritz, L.

PY - 2015/11/15

Y1 - 2015/11/15

N2 - Optical mapping is an important tool for assessment of cardiac electrophysiology. We demonstrate a system for quantification and automatic measurement of electrophysiological parameters in isolated cardiac tissue. The system makes use of voltage sensitive fluorescent dyes. These shift in wavelength in response to millivolt changes in potential across cell membranes located on the left atrium. Automated analysis of the pixel-wise measurements yields information on action potential durations and isochronal maps allowing for high throughput of data analysis. The algorithms that we propose reliably describe activation sequences and allow for quantification of conduction velocities.

AB - Optical mapping is an important tool for assessment of cardiac electrophysiology. We demonstrate a system for quantification and automatic measurement of electrophysiological parameters in isolated cardiac tissue. The system makes use of voltage sensitive fluorescent dyes. These shift in wavelength in response to millivolt changes in potential across cell membranes located on the left atrium. Automated analysis of the pixel-wise measurements yields information on action potential durations and isochronal maps allowing for high throughput of data analysis. The algorithms that we propose reliably describe activation sequences and allow for quantification of conduction velocities.

KW - optical mapping

KW - cardiovascular disease

KW - voltage imaging

KW - electrophysiology

KW - action potential

U2 - 10.1080/21681163.2015.1081079

DO - 10.1080/21681163.2015.1081079

M3 - Article

VL - 5

SP - 368

EP - 376

JO - Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization

JF - Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization

SN - 2168-1163

IS - 5

ER -