Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care

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Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care. / Roddy, Edward; Clarkson, Kris; Blagojevic-Bucknall, Milisa ; Mehta, Rajnikant ; Oppong, Raymond; Avery, Anthony; Hay, Elaine; Heneghan, Carl; Hartshorne, Liz ; Hooper, Julie ; Hughes, Gemma; Jowett, Sue; Lewis, Martyn; Little, Paul; McCartney, Karen ; Mahtani, Kamal ; Nunan, David; Santer, Miriam ; Williams, Sam ; Mallen, Christian.

In: Annals of the Rheumatic Diseases, Vol. 79, No. 2, 02.2020, p. 276-284.

Research output: Contribution to journalArticlepeer-review

Harvard

Roddy, E, Clarkson, K, Blagojevic-Bucknall, M, Mehta, R, Oppong, R, Avery, A, Hay, E, Heneghan, C, Hartshorne, L, Hooper, J, Hughes, G, Jowett, S, Lewis, M, Little, P, McCartney, K, Mahtani, K, Nunan, D, Santer, M, Williams, S & Mallen, C 2020, 'Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care', Annals of the Rheumatic Diseases, vol. 79, no. 2, pp. 276-284. https://doi.org/10.1136/annrheumdis-2019-216154

APA

Roddy, E., Clarkson, K., Blagojevic-Bucknall, M., Mehta, R., Oppong, R., Avery, A., Hay, E., Heneghan, C., Hartshorne, L., Hooper, J., Hughes, G., Jowett, S., Lewis, M., Little, P., McCartney, K., Mahtani, K., Nunan, D., Santer, M., Williams, S., & Mallen, C. (2020). Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care. Annals of the Rheumatic Diseases, 79(2), 276-284. https://doi.org/10.1136/annrheumdis-2019-216154

Vancouver

Author

Roddy, Edward ; Clarkson, Kris ; Blagojevic-Bucknall, Milisa ; Mehta, Rajnikant ; Oppong, Raymond ; Avery, Anthony ; Hay, Elaine ; Heneghan, Carl ; Hartshorne, Liz ; Hooper, Julie ; Hughes, Gemma ; Jowett, Sue ; Lewis, Martyn ; Little, Paul ; McCartney, Karen ; Mahtani, Kamal ; Nunan, David ; Santer, Miriam ; Williams, Sam ; Mallen, Christian. / Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care. In: Annals of the Rheumatic Diseases. 2020 ; Vol. 79, No. 2. pp. 276-284.

Bibtex

@article{9a2a7f2ed9214d328122bad2c628009a,
title = "Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care",
abstract = "Objectives: To compare the effectiveness and safety of naproxen and low-dose colchicine for treating gout flares in primary care. Methods: This was a multicentre open-label randomised trial. Adults with a gout flare recruited from 100 general practices were randomised equally to naproxen 750 mg immediately then 250 mg every 8 hours for 7 days or low-dose colchicine 500 mcg three times per day for 4 days. The primary outcome was change in worst pain intensity in the last 24 hours (0-10 Numeric Rating Scale) from baseline measured daily over the first 7 days: Mean change from baseline was compared between groups over days 1-7 by intention to treat. Results: Between 29 January 2014 and 31 December 2015, we recruited 399 participants (naproxen n=200, colchicine n=199), of whom 349 (87.5%) completed primary outcome data at day 7. There was no significant between-group difference in average pain-change scores over days 1-7 (colchicine vs naproxen: Mean difference-0.18; 95% CI-0.53 to 0.17; p=0.32). During days 1-7, diarrhoea (45.9% vs 20.0%; OR 3.31; 2.01 to 5.44) and headache (20.5% vs 10.7%; 1.92; 1.03 to 3.55) were more common in the colchicine group than the naproxen group but constipation was less common (4.8% vs 19.3%; 0.24; 0.11 to 0.54). Conclusion: We found no difference in pain intensity over 7 days between people with a gout flare randomised to either naproxen or low-dose colchicine. Naproxen caused fewer side effects supporting naproxen as first-line treatment for gout flares in primary care in the absence of contraindications. Trial registration number: ISRCTN (69836939), clinicaltrials.gov (NCT01994226), EudraCT (2013-001354-95).",
keywords = "Gout, Primary care, Naproxen, Colchicine, Randomised trial",
author = "Edward Roddy and Kris Clarkson and Milisa Blagojevic-Bucknall and Rajnikant Mehta and Raymond Oppong and Anthony Avery and Elaine Hay and Carl Heneghan and Liz Hartshorne and Julie Hooper and Gemma Hughes and Sue Jowett and Martyn Lewis and Paul Little and Karen McCartney and Kamal Mahtani and David Nunan and Miriam Santer and Sam Williams and Christian Mallen",
year = "2020",
month = feb,
doi = "10.1136/annrheumdis-2019-216154",
language = "English",
volume = "79",
pages = "276--284",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",
number = "2",

}

RIS

TY - JOUR

T1 - Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care

AU - Roddy, Edward

AU - Clarkson, Kris

AU - Blagojevic-Bucknall, Milisa

AU - Mehta, Rajnikant

AU - Oppong, Raymond

AU - Avery, Anthony

AU - Hay, Elaine

AU - Heneghan, Carl

AU - Hartshorne, Liz

AU - Hooper, Julie

AU - Hughes, Gemma

AU - Jowett, Sue

AU - Lewis, Martyn

AU - Little, Paul

AU - McCartney, Karen

AU - Mahtani, Kamal

AU - Nunan, David

AU - Santer, Miriam

AU - Williams, Sam

AU - Mallen, Christian

PY - 2020/2

Y1 - 2020/2

N2 - Objectives: To compare the effectiveness and safety of naproxen and low-dose colchicine for treating gout flares in primary care. Methods: This was a multicentre open-label randomised trial. Adults with a gout flare recruited from 100 general practices were randomised equally to naproxen 750 mg immediately then 250 mg every 8 hours for 7 days or low-dose colchicine 500 mcg three times per day for 4 days. The primary outcome was change in worst pain intensity in the last 24 hours (0-10 Numeric Rating Scale) from baseline measured daily over the first 7 days: Mean change from baseline was compared between groups over days 1-7 by intention to treat. Results: Between 29 January 2014 and 31 December 2015, we recruited 399 participants (naproxen n=200, colchicine n=199), of whom 349 (87.5%) completed primary outcome data at day 7. There was no significant between-group difference in average pain-change scores over days 1-7 (colchicine vs naproxen: Mean difference-0.18; 95% CI-0.53 to 0.17; p=0.32). During days 1-7, diarrhoea (45.9% vs 20.0%; OR 3.31; 2.01 to 5.44) and headache (20.5% vs 10.7%; 1.92; 1.03 to 3.55) were more common in the colchicine group than the naproxen group but constipation was less common (4.8% vs 19.3%; 0.24; 0.11 to 0.54). Conclusion: We found no difference in pain intensity over 7 days between people with a gout flare randomised to either naproxen or low-dose colchicine. Naproxen caused fewer side effects supporting naproxen as first-line treatment for gout flares in primary care in the absence of contraindications. Trial registration number: ISRCTN (69836939), clinicaltrials.gov (NCT01994226), EudraCT (2013-001354-95).

AB - Objectives: To compare the effectiveness and safety of naproxen and low-dose colchicine for treating gout flares in primary care. Methods: This was a multicentre open-label randomised trial. Adults with a gout flare recruited from 100 general practices were randomised equally to naproxen 750 mg immediately then 250 mg every 8 hours for 7 days or low-dose colchicine 500 mcg three times per day for 4 days. The primary outcome was change in worst pain intensity in the last 24 hours (0-10 Numeric Rating Scale) from baseline measured daily over the first 7 days: Mean change from baseline was compared between groups over days 1-7 by intention to treat. Results: Between 29 January 2014 and 31 December 2015, we recruited 399 participants (naproxen n=200, colchicine n=199), of whom 349 (87.5%) completed primary outcome data at day 7. There was no significant between-group difference in average pain-change scores over days 1-7 (colchicine vs naproxen: Mean difference-0.18; 95% CI-0.53 to 0.17; p=0.32). During days 1-7, diarrhoea (45.9% vs 20.0%; OR 3.31; 2.01 to 5.44) and headache (20.5% vs 10.7%; 1.92; 1.03 to 3.55) were more common in the colchicine group than the naproxen group but constipation was less common (4.8% vs 19.3%; 0.24; 0.11 to 0.54). Conclusion: We found no difference in pain intensity over 7 days between people with a gout flare randomised to either naproxen or low-dose colchicine. Naproxen caused fewer side effects supporting naproxen as first-line treatment for gout flares in primary care in the absence of contraindications. Trial registration number: ISRCTN (69836939), clinicaltrials.gov (NCT01994226), EudraCT (2013-001354-95).

KW - Gout

KW - Primary care

KW - Naproxen

KW - Colchicine

KW - Randomised trial

UR - http://www.scopus.com/inward/record.url?scp=85074476077&partnerID=8YFLogxK

U2 - 10.1136/annrheumdis-2019-216154

DO - 10.1136/annrheumdis-2019-216154

M3 - Article

VL - 79

SP - 276

EP - 284

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 2

ER -