Opening of the outer membrane protein channel in tripartite efflux pumps is induced by interaction with the membrane fusion partner.

Thamarai K Janganan; Vassiliy Bavro; L. Zhang; Dijana Matak-Vinkovic; Nelson P Barrera; Matthew Burton; Patrick  Steel; Carol V Robinson; Maria Inês Borges-Walmsley; Adrian R Walmsley

doi:10.1074/jbc.M110.187658

Opening of the outer membrane protein channel in tripartite efflux pumps is induced by interaction with the membrane fusion partner.

Thamarai K Janganan, Vassiliy Bavro, L. Zhang, Dijana Matak-Vinkovic, Nelson P Barrera, Matthew Burton, Patrick Steel, Carol V Robinson, Maria Inês Borges-Walmsley, Adrian R Walmsley

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Original language	English
Pages (from-to)	5484-5493
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	286
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M110.187658
Publication status	Published - Feb 2011

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.1074/jbc.M110.187658

http://www.ncbi.nlm.nih.gov/pubmed/21115481

24 Citations
4 Article

Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump
Janganan, T. K., Bavro, V., Zhang, L., Borges-Walmsley, M. I. & Walmsley, A. R., May 2013, In: Molecular Microbiology. 88, 3, p. 590-602 13 p.
Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus)
Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3
Janganan, T. K., Bavro, V. N., Zhang, L., Matak-Vinkovic, D., Barrera, N. P., Venien-Bryan, C., Robinson, C. V., Borges-Walmsley, M. I. & Walmsley, A. R., 2011, In: Journal of Biological Chemistry. 286, 30, p. 26900-12 13 p.
Research output: Contribution to journal › Article › peer-review
38 Citations (Scopus)
MacB ABC transporter is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA
Lin, H. T., Bavro, V. N., Barrera, N. P., Frankish, H. M., Velamakanni, S., van Veen, H. W., Robinson, C. V., Borges-Walmsley, M. I. & Walmsley, A. R., 2009, In: Journal of Biological Chemistry. 284, 2, p. 1145-54 10 p.
Research output: Contribution to journal › Article › peer-review
69 Citations (Scopus)
Assembly and channel opening in a bacterial drug efflux machine
Bavro, V. N., Pietras, Z., Furnham, N., Pérez-Cano, L., Fernández-Recio, J., Pei, X. Y., Misra, R. & Luisi, B., 2008, In: Molecular Cell. 30, 1, p. 114-21 8 p.
Research output: Contribution to journal › Article › peer-review
132 Citations (Scopus)

Cite this

Janganan, T. K., Bavro, V., Zhang, L., Matak-Vinkovic, D., Barrera, N. P., Burton, M., Steel, P., Robinson, C. V., Borges-Walmsley, M. I., & Walmsley, A. R. (2011). Opening of the outer membrane protein channel in tripartite efflux pumps is induced by interaction with the membrane fusion partner. Journal of Biological Chemistry, 286(7), 5484-5493. https://doi.org/10.1074/jbc.M110.187658

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title = "Opening of the outer membrane protein channel in tripartite efflux pumps is induced by interaction with the membrane fusion partner.",

author = "Janganan, {Thamarai K} and Vassiliy Bavro and L. Zhang and Dijana Matak-Vinkovic and Barrera, {Nelson P} and Matthew Burton and Patrick Steel and Robinson, {Carol V} and Borges-Walmsley, {Maria In{\^e}s} and Walmsley, {Adrian R}",

year = "2011",

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doi = "10.1074/jbc.M110.187658",

language = "English",

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Janganan, TK, Bavro, V, Zhang, L, Matak-Vinkovic, D, Barrera, NP, Burton, M, Steel, P, Robinson, CV, Borges-Walmsley, MI & Walmsley, AR 2011, 'Opening of the outer membrane protein channel in tripartite efflux pumps is induced by interaction with the membrane fusion partner.', Journal of Biological Chemistry, vol. 286, no. 7, pp. 5484-5493. https://doi.org/10.1074/jbc.M110.187658

TY - JOUR

T1 - Opening of the outer membrane protein channel in tripartite efflux pumps is induced by interaction with the membrane fusion partner.

AU - Janganan, Thamarai K

AU - Bavro, Vassiliy

AU - Zhang, L.

AU - Matak-Vinkovic, Dijana

AU - Barrera, Nelson P

AU - Burton, Matthew

AU - Steel, Patrick

AU - Robinson, Carol V

AU - Borges-Walmsley, Maria Inês

AU - Walmsley, Adrian R

PY - 2011/2

Y1 - 2011/2

U2 - 10.1074/jbc.M110.187658

DO - 10.1074/jbc.M110.187658

M3 - Article

SN - 0021-9258

VL - 286

SP - 5484

EP - 5493

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

Opening of the outer membrane protein channel in tripartite efflux pumps is induced by interaction with the membrane fusion partner.

ASJC Scopus subject areas

Access to Document

Research output

Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump

Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3

MacB ABC transporter is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA

Assembly and channel opening in a bacterial drug efflux machine

Cite this