Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells

Research output: Contribution to journalArticle

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Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. / Yin, Y; Henzl, MT; Lorber, Barbara; Nakazawa, E; Thomas, TT; Jiang, F; Langer, R; Benowitz, LI.

In: Nature Neuroscience, Vol. 9, No. 6, 14.05.2006, p. 843-852.

Research output: Contribution to journalArticle

Harvard

Yin, Y, Henzl, MT, Lorber, B, Nakazawa, E, Thomas, TT, Jiang, F, Langer, R & Benowitz, LI 2006, 'Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells', Nature Neuroscience, vol. 9, no. 6, pp. 843-852. https://doi.org/10.1038/nn1701

APA

Yin, Y., Henzl, MT., Lorber, B., Nakazawa, E., Thomas, TT., Jiang, F., Langer, R., & Benowitz, LI. (2006). Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nature Neuroscience, 9(6), 843-852. https://doi.org/10.1038/nn1701

Vancouver

Author

Yin, Y ; Henzl, MT ; Lorber, Barbara ; Nakazawa, E ; Thomas, TT ; Jiang, F ; Langer, R ; Benowitz, LI. / Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. In: Nature Neuroscience. 2006 ; Vol. 9, No. 6. pp. 843-852.

Bibtex

@article{3edb10a4851647bf944939345fa9b048,
title = "Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells",
abstract = "The optic nerve, like most mature CNS pathways, does not regenerate after injury. Through unknown mechanisms, however, macrophage activation in the eye stimulates retinal ganglion cells (RGCs) to regenerate long axons beyond the site of optic nerve injury. Here we identify the calcium (Ca(2+))-binding protein oncomodulin as a potent macrophage-derived growth factor for RGCs and other neurons. Oncomodulin binds to rat RGCs with high affinity in a cyclic AMP (cAMP)-dependent manner and stimulates more extensive outgrowth than other known trophic agents. Depletion of oncomodulin from macrophage-conditioned media (MCM) eliminates the axon-promoting activity of MCM. The effects of oncomodulin involve downstream signaling via Ca(2+)/calmodulin kinase and gene transcription. In vivo, oncomodulin released from microspheres promotes regeneration in the mature rat optic nerve. Oncomodulin also stimulates outgrowth from peripheral sensory neurons. Thus, oncomodulin is a new growth factor for neurons of the mature central and peripheral nervous systems.",
author = "Y Yin and MT Henzl and Barbara Lorber and E Nakazawa and TT Thomas and F Jiang and R Langer and LI Benowitz",
year = "2006",
month = may,
day = "14",
doi = "10.1038/nn1701",
language = "English",
volume = "9",
pages = "843--852",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells

AU - Yin, Y

AU - Henzl, MT

AU - Lorber, Barbara

AU - Nakazawa, E

AU - Thomas, TT

AU - Jiang, F

AU - Langer, R

AU - Benowitz, LI

PY - 2006/5/14

Y1 - 2006/5/14

N2 - The optic nerve, like most mature CNS pathways, does not regenerate after injury. Through unknown mechanisms, however, macrophage activation in the eye stimulates retinal ganglion cells (RGCs) to regenerate long axons beyond the site of optic nerve injury. Here we identify the calcium (Ca(2+))-binding protein oncomodulin as a potent macrophage-derived growth factor for RGCs and other neurons. Oncomodulin binds to rat RGCs with high affinity in a cyclic AMP (cAMP)-dependent manner and stimulates more extensive outgrowth than other known trophic agents. Depletion of oncomodulin from macrophage-conditioned media (MCM) eliminates the axon-promoting activity of MCM. The effects of oncomodulin involve downstream signaling via Ca(2+)/calmodulin kinase and gene transcription. In vivo, oncomodulin released from microspheres promotes regeneration in the mature rat optic nerve. Oncomodulin also stimulates outgrowth from peripheral sensory neurons. Thus, oncomodulin is a new growth factor for neurons of the mature central and peripheral nervous systems.

AB - The optic nerve, like most mature CNS pathways, does not regenerate after injury. Through unknown mechanisms, however, macrophage activation in the eye stimulates retinal ganglion cells (RGCs) to regenerate long axons beyond the site of optic nerve injury. Here we identify the calcium (Ca(2+))-binding protein oncomodulin as a potent macrophage-derived growth factor for RGCs and other neurons. Oncomodulin binds to rat RGCs with high affinity in a cyclic AMP (cAMP)-dependent manner and stimulates more extensive outgrowth than other known trophic agents. Depletion of oncomodulin from macrophage-conditioned media (MCM) eliminates the axon-promoting activity of MCM. The effects of oncomodulin involve downstream signaling via Ca(2+)/calmodulin kinase and gene transcription. In vivo, oncomodulin released from microspheres promotes regeneration in the mature rat optic nerve. Oncomodulin also stimulates outgrowth from peripheral sensory neurons. Thus, oncomodulin is a new growth factor for neurons of the mature central and peripheral nervous systems.

UR - http://www.scopus.com/inward/record.url?scp=33745712928&partnerID=8YFLogxK

U2 - 10.1038/nn1701

DO - 10.1038/nn1701

M3 - Article

C2 - 16699509

VL - 9

SP - 843

EP - 852

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 6

ER -