On your marks, get SET(D1A): the race to protect stalled replication forks
Research output: Contribution to journal › Comment/debate › peer-review
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On your marks, get SET(D1A): the race to protect stalled replication forks. / Begum, Shabana; Goula, Amalia; Bayley, Rachel; Higgs, Martin.
In: Molecular and Cellular Oncology, Vol. 5, No. 6, e1511209, 2018.Research output: Contribution to journal › Comment/debate › peer-review
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TY - JOUR
T1 - On your marks, get SET(D1A):
T2 - the race to protect stalled replication forks
AU - Begum, Shabana
AU - Goula, Amalia
AU - Bayley, Rachel
AU - Higgs, Martin
PY - 2018
Y1 - 2018
N2 - We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome stability with important implications in chemosensitivity.
AB - We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome stability with important implications in chemosensitivity.
KW - genome stability
KW - SETD1A
KW - FANCD2
KW - replication stress
KW - chemoresistance
U2 - 10.1080/23723556.2018.1511209
DO - 10.1080/23723556.2018.1511209
M3 - Comment/debate
VL - 5
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
SN - 2372-3556
IS - 6
M1 - e1511209
ER -