On your marks, get SET(D1A): the race to protect stalled replication forks

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On your marks, get SET(D1A): the race to protect stalled replication forks. / Begum, Shabana; Goula, Amalia; Bayley, Rachel; Higgs, Martin.

In: Molecular and Cellular Oncology, Vol. 5, No. 6, e1511209, 2018.

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@article{54015576f581476ba13d8524538300e4,
title = "On your marks, get SET(D1A):: the race to protect stalled replication forks",
abstract = "We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome stability with important implications in chemosensitivity.",
keywords = "genome stability, SETD1A, FANCD2, replication stress, chemoresistance",
author = "Shabana Begum and Amalia Goula and Rachel Bayley and Martin Higgs",
year = "2018",
doi = "10.1080/23723556.2018.1511209",
language = "English",
volume = "5",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - On your marks, get SET(D1A):

T2 - the race to protect stalled replication forks

AU - Begum, Shabana

AU - Goula, Amalia

AU - Bayley, Rachel

AU - Higgs, Martin

PY - 2018

Y1 - 2018

N2 - We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome stability with important implications in chemosensitivity.

AB - We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome stability with important implications in chemosensitivity.

KW - genome stability

KW - SETD1A

KW - FANCD2

KW - replication stress

KW - chemoresistance

U2 - 10.1080/23723556.2018.1511209

DO - 10.1080/23723556.2018.1511209

M3 - Comment/debate

VL - 5

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

SN - 2372-3556

IS - 6

M1 - e1511209

ER -