On your marks, get SET(D1A):: the race to protect stalled replication forks

Shabana Begum; Amalia Goula; Rachel Bayley; Martin Higgs

doi:10.1080/23723556.2018.1511209

On your marks, get SET(D1A): the race to protect stalled replication forks

Shabana Begum, Amalia Goula, Rachel Bayley, Martin Higgs

Cancer and Genomic Sciences

Research output: Contribution to journal › Comment/debate › peer-review

2 Citations (Scopus)

187 Downloads (Pure)

Abstract

We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome stability with important implications in chemosensitivity.

Original language	English
Article number	e1511209
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	6
Early online date	11 Oct 2018
DOIs	https://doi.org/10.1080/23723556.2018.1511209
Publication status	Published - 2018

Keywords

genome stability
SETD1A
FANCD2
replication stress
chemoresistance

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Begum_et_al_On_your_marks_get_set_(D1A)_Molecular_&_Cellular_Oncology_2018Final published version, 2.15 MBLicence: Creative Commons: Attribution (CC BY)

https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1511209Licence: Creative Commons: Attribution (CC BY)

2 Citations
1 Article

Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2
Higgs, M., Sato, K., Reynolds, J., Begum, S., Bayley, R., Goula, A., Vernet, A., Paquin, K., Skalnik, D., Kobayashi, W., Takata, M., Howlett, N., Kurumizaka, H., Kimura, H. & Stewart, G., 5 Jul 2018, In: Molecular Cell. 71, 1, p. 25-41.e6 23 p.
Research output: Contribution to journal › Article › peer-review

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37 Citations (Scopus)

229 Downloads (Pure)

Cite this

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title = "On your marks, get SET(D1A):: the race to protect stalled replication forks",

abstract = "We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome stability with important implications in chemosensitivity.",

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T2 - the race to protect stalled replication forks

AU - Begum, Shabana

AU - Goula, Amalia

AU - Bayley, Rachel

AU - Higgs, Martin

PY - 2018

Y1 - 2018

N2 - We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome stability with important implications in chemosensitivity.

AB - We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome stability with important implications in chemosensitivity.

KW - genome stability

KW - SETD1A

KW - FANCD2

KW - replication stress

KW - chemoresistance

U2 - 10.1080/23723556.2018.1511209

DO - 10.1080/23723556.2018.1511209

M3 - Comment/debate

SN - 2372-3556

VL - 5

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 6

M1 - e1511209

ER -

On your marks, get SET(D1A): the race to protect stalled replication forks

Abstract

Keywords

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Research output

Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2

Cite this