On your marks, get SET(D1A): the race to protect stalled replication forks
Research output: Contribution to journal › Comment/debate › peer-review
Colleges, School and Institutes
We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome stability with important implications in chemosensitivity.
- genome stability, SETD1A, FANCD2, replication stress, chemoresistance