Oligonucleotide therapies in the treatment of arthritis: a narrative review

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • University of Bath
  • National Heart and Lung Institute

Abstract

Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common chronic inflammatory joint diseases, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. The pathology of both OA and RA involves multiple tissues within the joint, including the synovial joint lining and the bone, as well as the articular cartilage in OA. In this review, we discuss the potential for the development of oligonucleotide therapies for these disorders by examining the evidence that oligonucleotides can modulate the key cellular pathways that drive the pathology of the inflammatory diseased joint pathology, as well as evidence in preclinical in vivo models that oligonucleotides can modify disease progression.

Details

Original languageEnglish
Article number902
Number of pages17
JournalBiomedicines
Volume9
Issue number8
Publication statusPublished - 27 Jul 2021

Keywords

  • osteoarthritis, rheumatoid arthritis, synovitis, cartilage, bone, antisense, oligonucleotides, therapeutics