Old drug, new tricks: haloperidol inhibits secretion of proinflammatory cytokines

Research output: Contribution to journalArticlepeer-review


  • Z Al-Saffar
  • D Hutchinson
  • S P Golding
  • P J McLaughlin

Colleges, School and Institutes


It was noted that treatment of a patient with acute mania by haloperidol was associated with marked improvement in activity of rheumatoid arthritis. The objective of this study was to examine the effects of haloperidol on inflammatory cytokine release in vitro, as a potential mechanism to explain the in vivo anti-inflammatory effects of haloperidol.


Original languageEnglish
Pages (from-to)585-7
Number of pages3
JournalAnnals of the Rheumatic Diseases
Issue number9
Publication statusPublished - Sep 1999


  • Haloperidol, Anti-Inflammatory Agents, Tumor Necrosis Factor-alpha, Culture Techniques, Tumor Cells, Cultured, Interleukin-1, Dose-Response Relationship, Drug, Humans, Adult, Arthritis, Rheumatoid, Antipsychotic Agents, Female