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Abstract
Objectives: We determined if eye movements evoked by Electrical Vestibular Stimulation (EVS) can be used to detect vestibular dysfunction in patients with unilateral vestibular schwannoma (VS).
Methods: Ocular torsion responses to monaural sinusoidal EVS currents (± 2mA, 2Hz) were measured in 25 patients with tumours ranging in size from Koos grade 1 to 3. For comparative purposes we also measured postural sway response to EVS, and additionally assessed vestibular function with the lateral Head Impulse Test (HIT). Patient responses were compared to age-matched healthy control subjects.
Results: Patients exhibited smaller ocular responses to ipsilesional versus contralesional EVS, and showed a larger asymmetry ratio (AR) than control subjects (19.4 vs. 3.3%, p<0.05). EVS-evoked sway responses were also smaller in ipsilesional ear, but exhibited slightly more variability than the eye movement response, along with marginally lower discriminatory power (patients vs. controls: AR=16.6 vs 2.6%, p<0.05). The HIT test exhibited no significant difference between groups.
Conclusions: These results demonstrate significant deficits in the ocular torsion response to EVS in VS patients.Significance: The fast, convenient and non-invasive nature of the test are well suited to clinical use.
Methods: Ocular torsion responses to monaural sinusoidal EVS currents (± 2mA, 2Hz) were measured in 25 patients with tumours ranging in size from Koos grade 1 to 3. For comparative purposes we also measured postural sway response to EVS, and additionally assessed vestibular function with the lateral Head Impulse Test (HIT). Patient responses were compared to age-matched healthy control subjects.
Results: Patients exhibited smaller ocular responses to ipsilesional versus contralesional EVS, and showed a larger asymmetry ratio (AR) than control subjects (19.4 vs. 3.3%, p<0.05). EVS-evoked sway responses were also smaller in ipsilesional ear, but exhibited slightly more variability than the eye movement response, along with marginally lower discriminatory power (patients vs. controls: AR=16.6 vs 2.6%, p<0.05). The HIT test exhibited no significant difference between groups.
Conclusions: These results demonstrate significant deficits in the ocular torsion response to EVS in VS patients.Significance: The fast, convenient and non-invasive nature of the test are well suited to clinical use.
Original language | English |
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Pages (from-to) | 2350-2360 |
Journal | Clinical Neurophysiology |
Volume | 129 |
Issue number | 11 |
Early online date | 8 Sept 2018 |
DOIs | |
Publication status | Published - Nov 2018 |
Keywords
- Vestibular Schwannoma
- Asymmetry ratio
- Electrical Vestibular Stimulation
- Head Impulse Test
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- 1 Finished
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The effect of ageing on vestibular control of balance
Biotechnology & Biological Sciences Research Council
3/10/11 → 2/10/13
Project: Research Councils