Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals

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Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals. / Mauro, Claudio; Smith, Joanne; Cucchi, Danilo; Coe, David; Fu, Hongmei; Bonacina, Fabrizia; Baragetti, Andrea; Cermenati, Gaia; Caruso, Donatella; Mitro, Nico; Catapano, Alberico L.; Ammirati, Enrico; Longhi, Maria P.; Okkenhaug, Klaus; Norata, Giuseppe D.; Marelli-berg, Federica M.

In: Cell Metabolism, Vol. 25, No. 3, 01.03.2017, p. 593-609.

Research output: Contribution to journalArticle

Harvard

Mauro, C, Smith, J, Cucchi, D, Coe, D, Fu, H, Bonacina, F, Baragetti, A, Cermenati, G, Caruso, D, Mitro, N, Catapano, AL, Ammirati, E, Longhi, MP, Okkenhaug, K, Norata, GD & Marelli-berg, FM 2017, 'Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals', Cell Metabolism, vol. 25, no. 3, pp. 593-609. https://doi.org/10.1016/j.cmet.2017.01.008

APA

Mauro, C., Smith, J., Cucchi, D., Coe, D., Fu, H., Bonacina, F., Baragetti, A., Cermenati, G., Caruso, D., Mitro, N., Catapano, A. L., Ammirati, E., Longhi, M. P., Okkenhaug, K., Norata, G. D., & Marelli-berg, F. M. (2017). Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals. Cell Metabolism, 25(3), 593-609. https://doi.org/10.1016/j.cmet.2017.01.008

Vancouver

Author

Mauro, Claudio ; Smith, Joanne ; Cucchi, Danilo ; Coe, David ; Fu, Hongmei ; Bonacina, Fabrizia ; Baragetti, Andrea ; Cermenati, Gaia ; Caruso, Donatella ; Mitro, Nico ; Catapano, Alberico L. ; Ammirati, Enrico ; Longhi, Maria P. ; Okkenhaug, Klaus ; Norata, Giuseppe D. ; Marelli-berg, Federica M. / Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals. In: Cell Metabolism. 2017 ; Vol. 25, No. 3. pp. 593-609.

Bibtex

@article{d189209b57574f09a67f07780650013f,
title = "Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals",
abstract = "Low-grade systemic inflammation associated toobesity leads to cardiovascular complications,caused partly by infiltration of adipose and vasculartissue by effector T cells. The signals leading toT cell differentiation and tissue infiltration duringobesity are poorly understood. We tested whethersaturated fatty acid-induced metabolic stress affectsdifferentiation and trafficking patterns of CD4+T cells.Memory CD4+T cells primed in high-fat diet-fed do-nors preferentially migrated to non-lymphoid, inflam-matory sites, independent of the metabolic status ofthe hosts. This was due to biased CD4+T cell differen-tiation into CD44hi-CCR7lo-CD62Llo-CXCR3+-LFA1+effector memory-like T cells upon priming in high-fat diet-fed animals. Similar phenotype was observedin obese subjects in a cohort of free-living people. Thisdevelopmental bias was independent of any cross-talk between CD4+T cells and dendritic cells andwas mediated via direct exposure of CD4+T cells topalmitate, leading to increased activation of a PI3Kp110δ-Akt-dependent pathway upon priming.",
keywords = "CD4, T lymphocyte, effector memory, differentiation, obesity, high-fat diet, inflammation, palmitate, saturated fatty acid, Akt",
author = "Claudio Mauro and Joanne Smith and Danilo Cucchi and David Coe and Hongmei Fu and Fabrizia Bonacina and Andrea Baragetti and Gaia Cermenati and Donatella Caruso and Nico Mitro and Catapano, {Alberico L.} and Enrico Ammirati and Longhi, {Maria P.} and Klaus Okkenhaug and Norata, {Giuseppe D.} and Marelli-berg, {Federica M.}",
year = "2017",
month = mar,
day = "1",
doi = "10.1016/j.cmet.2017.01.008",
language = "English",
volume = "25",
pages = "593--609",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals

AU - Mauro, Claudio

AU - Smith, Joanne

AU - Cucchi, Danilo

AU - Coe, David

AU - Fu, Hongmei

AU - Bonacina, Fabrizia

AU - Baragetti, Andrea

AU - Cermenati, Gaia

AU - Caruso, Donatella

AU - Mitro, Nico

AU - Catapano, Alberico L.

AU - Ammirati, Enrico

AU - Longhi, Maria P.

AU - Okkenhaug, Klaus

AU - Norata, Giuseppe D.

AU - Marelli-berg, Federica M.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Low-grade systemic inflammation associated toobesity leads to cardiovascular complications,caused partly by infiltration of adipose and vasculartissue by effector T cells. The signals leading toT cell differentiation and tissue infiltration duringobesity are poorly understood. We tested whethersaturated fatty acid-induced metabolic stress affectsdifferentiation and trafficking patterns of CD4+T cells.Memory CD4+T cells primed in high-fat diet-fed do-nors preferentially migrated to non-lymphoid, inflam-matory sites, independent of the metabolic status ofthe hosts. This was due to biased CD4+T cell differen-tiation into CD44hi-CCR7lo-CD62Llo-CXCR3+-LFA1+effector memory-like T cells upon priming in high-fat diet-fed animals. Similar phenotype was observedin obese subjects in a cohort of free-living people. Thisdevelopmental bias was independent of any cross-talk between CD4+T cells and dendritic cells andwas mediated via direct exposure of CD4+T cells topalmitate, leading to increased activation of a PI3Kp110δ-Akt-dependent pathway upon priming.

AB - Low-grade systemic inflammation associated toobesity leads to cardiovascular complications,caused partly by infiltration of adipose and vasculartissue by effector T cells. The signals leading toT cell differentiation and tissue infiltration duringobesity are poorly understood. We tested whethersaturated fatty acid-induced metabolic stress affectsdifferentiation and trafficking patterns of CD4+T cells.Memory CD4+T cells primed in high-fat diet-fed do-nors preferentially migrated to non-lymphoid, inflam-matory sites, independent of the metabolic status ofthe hosts. This was due to biased CD4+T cell differen-tiation into CD44hi-CCR7lo-CD62Llo-CXCR3+-LFA1+effector memory-like T cells upon priming in high-fat diet-fed animals. Similar phenotype was observedin obese subjects in a cohort of free-living people. Thisdevelopmental bias was independent of any cross-talk between CD4+T cells and dendritic cells andwas mediated via direct exposure of CD4+T cells topalmitate, leading to increased activation of a PI3Kp110δ-Akt-dependent pathway upon priming.

KW - CD4

KW - T lymphocyte

KW - effector memory

KW - differentiation

KW - obesity

KW - high-fat diet

KW - inflammation

KW - palmitate

KW - saturated fatty acid

KW - Akt

U2 - 10.1016/j.cmet.2017.01.008

DO - 10.1016/j.cmet.2017.01.008

M3 - Article

VL - 25

SP - 593

EP - 609

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 3

ER -